Using a Menstrual Cup to Collect Uterine Lining for Early Endometrial Cancer Screening in Women with Lynch Syndrome

What this Trial Is About

Researchers are studying a non-invasive method to collect uterine lining samples using a menstrual cup to help screen for endometrial cancer, particularly in women with Lynch syndrome, a genetic condition increasing cancer risk. This pilot trial aims to see if menstrual cup samples can replace or complement the usual endometrial biopsy method and to explore if lab-grown uterine models can be created from these samples. Participants will use a menstrual cup at home during menstruation to collect uterine lining fluid. They will also undergo a standard endometrial biopsy performed by a healthcare provider. The study consists of a pre-pilot phase with 5 menstruating women and a main pilot phase involving 20 women with Lynch syndrome undergoing routine biopsy screening. Both sample types will be compared for quality and usefulness, and participant and provider satisfaction will be assessed. During the study, participants will complete surveys about their experience using the menstrual cup. Researchers will evaluate how well participants collect and send samples, the quality of tissue obtained, and the success of growing organoids from the samples. The main outcome measured is the adequacy of samples for pathological evaluation. The trial will monitor participant comfort and feasibility over about one year, including follow-up assessments after sample collection.

Menstrual Cup for Early Endometrial Cancer Detection in Lynch Syndrome