+1 877 705 191424 / 7
HIPAA Compliant
ISO 27001 Certified

Actively Recruiting

Phase Not Applicable
Age: 18Years - 45Years
All Genders
ID06335784

Mental Imagery and Targeted Memory Reactivation in Insomnia Disorder

Led by University Hospital, Geneva · Updated on 2026-03-03

120

Participants Needed

1

Research Sites

13 weeks

Total Duration

On this page

Sponsors

U

University Hospital, Geneva

Lead Sponsor

U

University of Geneva, Switzerland

Collaborating Sponsor

AI-Summary

What this Trial Is About

Researchers are studying whether mental Imagery Rescripting IR, a technique where a negative memory or image is transformed into a positive one, combined with olfactory Targeted Memory Reactivation TMR, which uses smells to strengthen memories during sleep, can reduce hyperarousal and insomnia severity in adults with Insomnia Disorder. The study compares these methods to sleep hygiene education and examines their effects on improving insomnia symptoms. Participants will be randomly assigned to one of four groups a sleep hygiene group receiving weekly sessions and using an odorless diffuser an IR group receiving weekly sessions of Imagery Rescripting along with daily home practice using an odorless diffuser a TMR group receiving the same IR sessions paired with a specific odor diffused during sleep and an odor alone group receiving sleep hygiene sessions with an odor diffused at night. Patients with ongoing symptoms after these interventions may try a rocking bed treatment where they are rocked during sleep for one night. Participants will be evaluated before and after treatment using the Insomnia Severity Index ISI as the primary measure, along with other assessments of sleep quality, total sleep time, wake after sleep onset, depression, anxiety, sleep efficiency, and micro-arousals. Assessments occur at baseline, 5 weeks, and 3 months. The study includes weekly sessions over 4 weeks with daily home practices, and follow-up evaluations to monitor changes in insomnia severity and sleep quality.

CONDITIONS

Brief Title

Mental Imagery and Targeted Memory Reactivation in Insomnia

Who Can Participate

Age: 18Years - 45Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age between 18 and 45 years
  • Diagnosis of Insomnia Disorder according to the International Classification of Diseases 3 (ICSD-3)
  • Insomnia Severity Index (ISI) score greater than 10
  • Pittsburgh Sleep Quality Index (PSQI) score greater than 5
  • No current treatment for insomnia
Not Eligible

You will not qualify if you...

  • Presence of another psychiatric disorder requiring acute treatment according to DSM-5
  • Medical or other disorders explaining insomnia symptoms (e.g., neurological disorders, sleep apnea with ODI >15/h, restless legs syndrome, periodic limb movements >15, chronic pain)
  • Significant substance use or withdrawal
  • Heavy smoking
  • Known pregnancy
  • Anosmia, olfactory issues, or respiratory pathology

Research Team

L

Lampros Perogamvros

K

Kevin Mammeri

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here