Actively Recruiting
Menthol for Dyspnea Relief in Health and COPD
Led by KU Leuven · Updated on 2025-11-19
120
Participants Needed
1
Research Sites
304 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Menthol inhalation (MI) is a novel and promising treatment option for acute relief of dyspnea, however, the underlying ventilatory and/or neural related mechanisms for this relief in symptoms remain unknown. The overall aim of this research project is to systematically examine the mechanisms of dyspnea relief from MI in healthy individuals and those with COPD.
CONDITIONS
Official Title
Menthol for Dyspnea Relief in Health and COPD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Able to speak, read, and write Dutch or English
- Normal lung function with FEV1/FVC ratio >0.70 and FEV1 80% predicted (for healthy volunteer groups only)
- Non-smoker or former smoker abstinent for at least 12 months (for healthy volunteer groups only)
- Clinically stable COPD without recent exacerbations requiring increased medication within 14 days (for COPD groups only)
You will not qualify if you...
- Contraindications to exercise testing such as serious heart, muscle, or nerve diseases
- Significant lung or other diseases affecting breathing or exercise, except COPD in relevant groups
- Body mass index less than 18.5 or greater than 35 kg/m2
- Ulcer or tumor in the esophagus, nasal septum deviation, or recent nasal/throat surgery
- Severe facial injury including damage to the bone between brain and nasal cavity
- Allergies to latex or sensitivity to local anesthetics
- Unable to give informed consent, including significant cognitive impairment
- Alcohol use within 12 hours before study visit
- Current smoker
- History of early menopause before age 45
- Pregnancy or planning pregnancy during the study
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University Hospital Leuven
Leuven, Belgium, 3000
Actively Recruiting
Research Team
D
Daniel Langer
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
13
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