Actively Recruiting
Menthol Stimulation of Brown Adipose Tissue in Humans: Aim 1
Led by Indiana University · Updated on 2025-06-25
24
Participants Needed
1
Research Sites
74 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Brown adipose tissue becomes activated during cold conditions to increase thermogenesis (i.e., energy expenditure). Topical menthol application increases resting energy expenditure but it is unclear whether brown adipose tissue activation contributes to this rise in the energy expenditure. The overall goal with this project is to determine whether topical menthol application stimulates brown adipose tissue.
CONDITIONS
Official Title
Menthol Stimulation of Brown Adipose Tissue in Humans: Aim 1
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Fluent in English
- Participate in 150 minutes or more of at least moderate intensity exercise per week during the previous year
- Body fat 30% or less as determined by DEXA scan
- Cleared for physical activity according to the 2020 Physical Activity Readiness Questionnaire (PAR-Q+)
You will not qualify if you...
- Any autonomic cardiovascular, metabolic, neurologic, endocrine, or respiratory disease deemed exclusionary by the investigator
- Previously diagnosed liver or kidney dysfunction including acute or chronic kidney disease, cirrhosis, hepatitis, or fatty liver disease
- Women who are pregnant or breastfeeding
- Current or regular tobacco or electronic cigarette use more than twice a week in the past year
- History of peripheral cold injury, skin disorders such as eczema or psoriasis, or excessive tattooing
- Known chronic or acute conditions of the rectum
- Allergy to menthol
- Use of medications with direct effects on the cardiovascular system including anticoagulants, antiplatelet agents, ACE inhibitors, angiotensin II receptor blockers, angiotensin-receptor neprilysin inhibitors, beta blockers, calcium/potassium/sodium channel blockers, cholesterol lowering medications, digitalis preparations, diuretics, vasodilators, or anticholinergics
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Indiana University
Bloomington, Indiana, United States, 47405
Actively Recruiting
Research Team
F
Felipe Pereira, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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