Actively Recruiting
MEP Up-conditioning to Target Corticospinal Plasticity
Led by Medical University of South Carolina · Updated on 2026-03-30
11
Participants Needed
1
Research Sites
96 weeks
Total Duration
On this page
Sponsors
M
Medical University of South Carolina
Lead Sponsor
D
Doscher Neurorehabilitation Research Program
Collaborating Sponsor
AI-Summary
What this Trial Is About
Individuals with chronic cervical spinal cord injury will complete a 10-week training protocol where participants receive non-invasive brain stimulation and feedback on the size of the corresponding muscle response (wrist extensor). Investigators will assess the impact of the brain stimulation training on 1) the brain-to-spinal cord-to-muscle connection and 2) motor functions of the arm and hand. Also, brain and spine magnetic resonance imaging will be collected before and after the training. The imaging measurements will tell investigators about how spinal damage, brain function, and brain structure relate to motor presentation and the response to the training.
CONDITIONS
Official Title
MEP Up-conditioning to Target Corticospinal Plasticity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult (≥18 years old)
- History of spinal cord injury at or above C6
- More than 6 months since spinal cord injury
- Weak wrist extension on at least one side
- Stable medication use expected for at least 3 months, including anti-spasticity drugs if used
You will not qualify if you...
- Motoneuron injury
- Medically unstable condition
- Cognitive impairment
- History of epileptic seizures
- Metal implants in the cranium
- Implanted biomedical devices in or above the chest (e.g., pacemaker, cochlear implant)
- Daily extensive use of functional electrical stimulation on the arm
- Pregnancy
- Contraindications to MRI
- No measurable motor evoked potential in the extensor carpi radialis
- Unable to produce any voluntary extensor carpi radialis muscle activity
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Medical University of South Carolina
Charleston, South Carolina, United States, 29425
Actively Recruiting
Research Team
R
Recruitment Contact
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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