Actively Recruiting
Meropenem vs Azithromycin Efficacy in Case XDR Enteric Fever
Led by Indus Hospital and Health Network · Updated on 2026-05-08
40
Participants Needed
1
Research Sites
90 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
1. Primary Objective: o To evaluate the efficacy of intravenous azithromycin compared with meropenem in the treatment of extensively drug-resistant (XDR) enteric fever. 2. Secondary Objectives: * To evaluate the fever defervescence and Salmonella Typhi eradication * To evaluate the cost-effectiveness of intravenous azithromycin versus meropenem in treating XDR enteric fever. 3. Exploratory Objectives: * To evaluate the drug resistance against intravenous azithromycin versus in treating XDR enteric fever.
CONDITIONS
Official Title
Meropenem vs Azithromycin Efficacy in Case XDR Enteric Fever
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Voluntarily sign the written informed consent
- Age between 1 and 70 years with clinically suspected or confirmed XDR enteric fever by blood culture and sensitivity
- Married females must have a negative pregnancy test
- No history of cardiac issues or ECG abnormalities and no cholestatic jaundice or liver problems linked to prior azithromycin use
- No hypersensitivity to azithromycin or meropenem
- Patients on medications without drug interactions with meropenem or azithromycin
You will not qualify if you...
- Pregnant or breastfeeding women, or women of childbearing age with a positive pregnancy test at baseline
- Known hypersensitivity to azithromycin, meropenem, or other macrolide or carbapenem antibiotics
- Blood culture positive for multidrug-resistant Salmonella typhi
- History of cardiac disorders with ECG abnormalities or cholestatic jaundice/hepatic dysfunction linked to prior azithromycin use
- Patients on continuous medications that interact with meropenem or azithromycin
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Indus Hospital & Health Network - Mian Campus
Karachi, Sindh, Pakistan
Actively Recruiting
Research Team
M
muhammad hamid, PharmD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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