Actively Recruiting
Metabolic and Bio-behavioral Effects of Following Recommendations in the Dietary Guidelines for Americans
Led by USDA, Western Human Nutrition Research Center · Updated on 2026-04-30
70
Participants Needed
1
Research Sites
217 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study, at the Western Human Nutrition Research Center (WHNRC), will focus on whether or not achieving and maintaining a healthy body weight is the most important health promoting recommendation of the Dietary Guidelines for Americans (DGA).The investigators hypothesize that improvement in cardiometabolic risk factors resulting from eating a DGA style diet will be greater in people whose energy intake is restricted to result in weight loss compared to those who maintain their weight. The investigators further propose that during a state of energy restriction, a higher nutrient quality diet such as the DGA style diet pattern, will result in greater improvement in cardiometabolic risk factors compared to a typical American diet (TAD) pattern that tends to be lower nutrient quality (more energy-dense and less nutrient-rich.)
CONDITIONS
Official Title
Metabolic and Bio-behavioral Effects of Following Recommendations in the Dietary Guidelines for Americans
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Body Mass Index (BMI) 23-39.9 kg/m2 or 32-50% body fat percentage
- Willingness to have blood drawn
- Fasting glucose between 100 mg/dL and less than 126 mg/dL or fasting triglyceride at least 125 mg/dL or HDL-cholesterol 50 mg/dL or less or systolic blood pressure at least 130 mmHg or diastolic blood pressure at least 85 mmHg or hemoglobin A1C between 5.7 and less than 6.5%
You will not qualify if you...
- Active participation in another research study
- Tested positive for COVID-19 within the past 10 days
- Been in close contact with a COVID-19 positive person within the past 14 days
- Systolic blood pressure 140 mmHg or higher or diastolic blood pressure 90 mmHg or higher
- LDL cholesterol 190 mg/dL or higher
- Triglycerides 500 mg/dL or higher
- Current use of smoking or chewing tobacco, e-cigarettes, cigars, vaping, cannabis or nicotine products within the past 6 months
- Current use of dietary supplements or unwillingness to stop supplement intake
- Vegan or vegetarian or other dietary restrictions interfering with consuming study foods
- Unwillingness to consume intervention foods and beverages
- More than moderate drinking (>1 drink per day) or binge drinking
- Unwillingness to stop alcohol intake as required
- Excessive caffeine intake (400 mg/day or more) or unwillingness to refrain from caffeine on lab days
- Intentional weight change of 5% or more within 6 months before study
- Diagnosis of disordered eating or eating disorder
- Recent anemia or abnormal liver or thyroid function based on lab tests
- History of gastric bypass surgery, inflammatory bowel disease, active cancer in past 3 years (except certain skin cancers), or serious medical conditions
- Recent dental work or oral conditions interfering with study foods
- Use of antipsychotic medications
- Long-term antibiotic use
- Use of medications for elevated lipids, glucose, blood pressure, weight loss, or corticosteroids
- Pregnant, planning pregnancy during study, or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UC Davis, Western Human Nutrition Research Center
Davis, California, United States, 95616
Actively Recruiting
Research Team
B
Beverly Miller, BS, RDN
CONTACT
E
Ellen Bonnel, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here