Actively Recruiting
Metabolic Control of Aging and Disease - the MetAGE Deep Phenotyping Cohort
Led by Thomas Scherer · Updated on 2026-02-17
650
Participants Needed
2
Research Sites
556 weeks
Total Duration
On this page
Sponsors
T
Thomas Scherer
Lead Sponsor
M
Medical University of Graz
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this prospective observational study is to identify and validate blood based aging biomarkers in relation to cardiometabolic phenotypes of young and old, female and male subjects with or without obesity. The main question is to gain insights into the interaction of obesity related metabolic alteration and aging, and the relevance of loss of metabolic control in the development of age-related diseases in order to build a foundation for targeted drug- and lifestyle interventions in future studies.
CONDITIONS
Official Title
Metabolic Control of Aging and Disease - the MetAGE Deep Phenotyping Cohort
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 35 years with BMI between 18.5 and 24.9 for lean young adults
- Age 18 to 35 years with BMI 28 or higher for overweight young adults
- Age 60 years or older with BMI between 18.5 and 24.9 for lean older adults
- Age 60 years or older with BMI 28 or higher for overweight older adults
- Subgroup of overweight older adults with pre-existing cardiovascular disease
- Subgroup of overweight older adults without pre-existing cardiovascular disease
- Age 90 years or older with BMI 18.5 or higher for nonagenarians
You will not qualify if you...
- Highly physically active (more than 5 times per week with moderate to high intensity)
- Following special diets such as ketogenic or time-restricted eating
- Clinically significant metabolic or endocrine disorders (including diabetes, overt hypo/hyperthyroidism for older adults)
- Claustrophobia
- Drug abuse or alcohol consumption exceeding 15 drinks per week
- Heart failure, cardiovascular disease, immunosuppressive therapies, chronic inflammatory diseases, and active cancer conditions (with specific age and group details)
- Metal implants that prevent 3T MRI scanning
- Pregnancy or breastfeeding
- Active anti-obesity treatment with medications such as GLP-1 analogues, polyagonists, naltrexone, or bupropion
- Known severe cardiovascular diseases including peripheral artery disease stage IIa or higher, advanced heart failure with LVEF below 35%, or NYHA Class III-IV
- Clinically significant cognitive impairment affecting study adherence
- Life-threatening conditions with less than 1 year life expectancy or other conditions jeopardizing safety or adherence
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Medical University of Vienna
Vienna, State of Vienna, Austria
Actively Recruiting
2
Medical University of Graz
Graz, Styria, Austria
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
5
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