Actively Recruiting
The Metabolic Effects of Intermittent Fasting
Led by University of Pittsburgh · Updated on 2025-08-07
90
Participants Needed
1
Research Sites
244 weeks
Total Duration
On this page
Sponsors
U
University of Pittsburgh
Lead Sponsor
N
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Caloric restriction has beneficial metabolic effects in humans including weight loss and improvement in blood pressure and lipid levels. Intermittent fasting has emerged as a popular alternative to caloric restriction as it does not require daily adherence to a dietary protocol, but whether the benefits of fasting protocols are dependent on weight loss is not known. In this study, the investigators will explore the metabolic effects of fasting and evaluate whether these effects, including negative effects on bone metabolism, are independent of weight loss.
CONDITIONS
Official Title
The Metabolic Effects of Intermittent Fasting
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men and women, ages 21 to 45 years
- BMI between 21 and 29 kg/m2
- Normal thyroid function
- Regular menstrual cycles (women)
- At least one first-degree relative with type 2 diabetes or history of gestational diabetes
You will not qualify if you...
- Presence of chronic diseases including hypertension and type 2 diabetes
- Need for lipid-lowering therapy per AHA guidelines (LDL >190 or 10-year ASCVD risk >7.5%)
- Use of chronic medications, including oral contraceptive pills
- Pregnancy or breastfeeding
- History of an eating disorder
- Vitamin D level below 20 ng/mL
- Active substance abuse, including alcohol
- Prior history of intermittent fasting
- Considered by study physician as unable to safely complete the protocol or at risk by participation
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
Research Team
P
Pouneh Fazeli, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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