Actively Recruiting
Metabolic Effects of Short-Chain Fatty Acids in Healthy Individuals
Led by University of Copenhagen · Updated on 2026-03-10
10
Participants Needed
1
Research Sites
259 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The primary objective of this study is to investigate the acute physiological and metabolic effects of ingesting the short-chain fatty acids (SCFA)s propionate (three carbon atoms long; C3:0) and butyrate (C4:0) in healthy men and women. This aim will be addressed through a block-randomized cross-over study including two visits with acute intake of propionate and butyrate, respectively. The hypothesis is that plasma ketone body levels will increase during the first three hours after intake of butyrate, but not propionate, in healthy individuals in the overnight fasted state.
CONDITIONS
Official Title
Metabolic Effects of Short-Chain Fatty Acids in Healthy Individuals
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female
- Age between 18-40 years old
- Body mass index (BMI) between 18.5 and 29
You will not qualify if you...
- Diabetes
- Kidney or liver disease
- Pregnant, breastfeeding, or planning pregnancy within the study period
- Using short-chain fatty acid supplements
- Using vitamin B12 supplements
- Following special diets such as vegan or ketogenic
- Undergoing cancer treatment
- Having metabolic or absorption disorders, gastric bypass, or medications affecting metabolism or absorption
- Diagnosed with Crohn's disease, ulcerative colitis, or short bowel syndrome
- Unable to comply physically or mentally with study procedures as determined by the study team
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Copenhagen
Copenhagen, Copenhagen N, Denmark, 2200
Actively Recruiting
Research Team
A
Amalie S Frederiksen, PhD student
CONTACT
A
Andreas M Fritzen, Associate Professor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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