Actively Recruiting
Metabolic Effects of Short-term Ultra-processed Food Intake (MEST-UPF)
Led by Göteborg University · Updated on 2025-12-15
24
Participants Needed
1
Research Sites
21 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The overall aim of this project is to study the effects of short-term high ultra-processed food intake, compared to nutrient- and energy density matched low ultra-processed food (UPF) intake, on energy intake and appetite. A total of 24 men and women who meet all inclusion criteria and none of the exclusion criteria will be invited to participate. A randomized 2\*2 factorial four-way crossover study will be conducted at the Department of Internal medicine and Clinical Nutrition at the University of Gothenburg, comparing a high-UPF meal to a low-UPF meal also with high and/or low energy density. A supervised breakfast meal will be served, and postprandial blood samples and appetite measures will be collected continuously up to 4 hours after the breakfast meal. Subsequently, an ad libitum lunch meal will be served, and energy intake will be recorded.
CONDITIONS
Official Title
Metabolic Effects of Short-term Ultra-processed Food Intake (MEST-UPF)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Body mass index (BMI) 18.5-30 kg/m2
- Fasting glucose less than 6.1 mmol/l
- Hemoglobin greater than 110 g/L
- Weight stable within +/- 5% during the last 3 months
You will not qualify if you...
- Food allergies, intolerances, or preferences preventing consumption of study foods
- Unable to understand written and spoken Swedish or English to provide consent and follow instructions
- Pregnant, lactating, or planning pregnancy during the study
- Blood donation or participation in a study with blood sampling within 30 days before screening or during the study
- History of gastrointestinal conditions or major gastrointestinal surgery
- Type 1 or type 2 diabetes
- Thyroid disorder
- Current smoking or vaping
- Following or having followed a weight reduction program within the last 6 months
- Not regularly eating breakfast (less than 5 times per week)
- Restrained eating based on the three-factor eating questionnaire
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Department of internal medicine and clinical nutrition, University olf Gothenburg
Gothenburg, Sweden, 40530
Actively Recruiting
Research Team
T
Therese Karlsson, PhD
CONTACT
L
Linnea Bärebring, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
PREVENTION
Number of Arms
4
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