Actively Recruiting
Metabolic Endpoints for Obstructive Sleep Apnea Following Twelfth Cranial Nerve Stimulation
Led by University of Chicago · Updated on 2026-01-28
30
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to determine if the treatment of Obstructive sleep apnea (OSA) by hypoglossal nerve stimulation (HGNS) will alter glucose metabolism. The study team will also determine if the treatment of Obstructive sleep apnea (OSA) by (hypoglossal nerve stimulation) HGNS will alter predictors of cardiovascular outcomes.
CONDITIONS
Official Title
Metabolic Endpoints for Obstructive Sleep Apnea Following Twelfth Cranial Nerve Stimulation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Overweight or obese males and females with BMI 25 kg/m2 to 40 kg/m2
- Age 18 years and older
- Diagnosed with obstructive sleep apnea by Apnea-Hypopnea Index >15 events/hr using 4% oxygen desaturation criteria and <25% central events/hr on prior sleep testing
- Not able to use positive airway pressure >4 hours for 5 nights/week or unwilling to use positive airway pressure
You will not qualify if you...
- Insulin-dependent Diabetes
- Inability to undergo in-lab polysomnography or home sleep testing
- Central Nervous System disease with cognitive impairment or muscle weakness (e.g., stroke)
- Currently pregnant, trying to get pregnant, or nursing
- Age under 18 years
- Regular and adherent CPAP use per clinical guidelines
- Current night shift or rotating shift work
- Diagnosis of another sleep disorder (e.g., periodic limb movement disorder)
- Current systemic steroid use
- Predominantly central sleep apnea or requiring advanced positive airway pressure modalities
- Protected patient under legal guardianship or hospitalized without consent
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
The University of Chicago
Chicago, Illinois, United States, 60637
Actively Recruiting
Research Team
P
Phillip LoSavio, MD, MS
CONTACT
C
Carlisa Dixon
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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