Impact of Ageing on Female Metabolic Flexibility: A Cross-Sectional Pilot Study in over-60 Active Women.
Jordi Monferrer-Marín, Ainoa Roldán, Pablo Monteagudo...
https://pubmed.ncbi.nlm.nih.gov/35907092Actively Recruiting
Phase Not Applicable
Age: 35Years - 75Years
FEMALE
ID06336070
Postmenopausal Oncological Women Exercising for Recovery of Health: Effects on Metabolic Flexibility and Autonomic Control After Muscle Power vs Metabolic Power Training
Led by University of Valencia · Updated on 2024-04-04
56
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
Sponsors
U
University of Valencia
Lead Sponsor
G
Generalitat Valenciana
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating metabolic flexibility and autonomic function, which describe cardiovascular health, in postmenopausal women who have survived breast cancer without recurrence compared to postmenopausal women without cancer. This clinical trial also aims to analyze how two different supervised 8-week exercise programs impact these cardiovascular capacities in these groups. The study focuses on breast cancer, the most common cancer among Spanish women, and its close link to cardiovascular diseases, especially after menopause. Participants will be randomly assigned to one of two exercise interventions lasting 8 weeks: a High Intensity Interval Training (HIIT) program focused on improving metabolic power with 30-minute sessions three times a week, or a Muscle Power Intervention (MPI) program focused on strength with 45-minute sessions twice a week. Both programs are professionally supervised with adapted intensities. Two cohorts are included: postmenopausal breast cancer survivors and postmenopausal women without cancer, each divided between the two exercise programs. During the study, participants will undergo assessments before and after the 8-week interventions, including fat oxidation during an incremental test and analysis of heart rate variability to measure autonomic function. Additional measures include weight, body composition, blood pressure, oxygen saturation, physical activity levels, muscle power, metabolic rate, and heart function. This mixed cross-sectional and longitudinal study is designed to contribute to better cardiovascular health and quality of life for postmenopausal women, with follow-up lasting throughout the 8-week intervention period.
CONDITIONS
Brief Title
Metabolic Flexibility and Autonomic Control After Muscle Power vs Metabolic Power Training in Postmenopausal Oncological Women: the POWER Health Study
Who Can Participate
Age: 35Years - 75Years
FEMALE
Eligibility Criteria
You may qualify if you...
- Women diagnosed with breast cancer who are free of recurrence or women without any cancer diagnosis in the last 15 years
- Aged between 35 and 75 years
- Postmenopausal status
- Not participating in any nutritional or dietary intervention
- Physically inactive, defined as no exercise program in the last 3 months or less than 600 METS/week of moderate to vigorous activity
- Able and willing to give informed consent
- No conditions that would make exercise unsafe or prevent testing, as determined by research staff
You will not qualify if you...
- Medical reasons preventing safe engagement in exercise
- Planned additional surgery during the intervention period
- Regular use of beta blockers or drugs affecting nervous system function
- History of another primary invasive cancer or serious chronic illness
- Specific heart conditions including recent myocardial infarction or coronary procedures, uncontrolled high blood pressure, uncontrolled arrhythmias, significant valve disease, decompensated heart failure, or known aortic aneurysm
AI-Screening
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Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - 8 weeks
Participants engage in supervised exercise interventions aimed at improving metabolic flexibility and autonomic health. One group participates in a High Intensity Interval Training (HIIT) program three times per week, while another group participates in a Muscle Power Intervention (MPI) program twice per week. Both exercise programs last 8 weeks with professional supervision and intensity adjustments.
3 sessions per week for HIIT or 2 sessions per week for MPI, all supervised
Trial Site Locations
Total: 1 location
1
Faculty of Physical Activity and Sport Sciences
Valencia, Valencia, Spain, 46010
Actively Recruiting
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Research Team
C
Cristina Blasco Lafarga, Tenured Professor
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Published Research Related To This Trial
Metabolic Flexibility and Mechanical Efficiency in Women Over-60.
Cristina Blasco-Lafarga, Jordi Monferrer-Marín, Ainoa Roldán...
https://pubmed.ncbi.nlm.nih.gov/35464093The influence of age, sex and cardiorespiratory fitness on maximal fat oxidation rate.
J Frandsen, F J Amaro-Gahete, A Landgrebe...
https://pubmed.ncbi.nlm.nih.gov/33848440Associations between heart rate variability and maximal fat oxidation in two different cohorts of healthy sedentary adults.
Anabel González-Acedo, Abel Plaza-Florido, Francisco José Amaro-Gahete...
https://pubmed.ncbi.nlm.nih.gov/35977864Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease.
Reuben L Smith, Maarten R Soeters, Rob C I Wüst...
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D Søgaard, M T Lund, C M Scheuer...
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Carolina Formighieri, Diana C Müller, Mikel L Sáez de Asteasu...
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Hendrik Mugele, Nils Freitag, Jannik Wilhelmi...
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