Parameters Associated With Metabolic Response to Volume Expansion in Children Post-operative of Cardiac Surgery

What this Trial Is About

Researchers are studying metabolic fluid responsiveness in children who experience acute circulatory failure after cardiac surgery. The goal is to find markers that help doctors decide which children might benefit from fluid expansion, avoiding unnecessary and potentially harmful fluid overload. This study focuses on evaluating the accuracy of a blood marker ratio called Pv-aCO2 to CavO2 to diagnose metabolic fluid responsiveness, defined as a significant increase in oxygen consumption after fluid expansion. This non-interventional, multicenter study in pediatric intensive care units involves children up to 15 years old who have had cardiac surgery and require fluid expansion as prescribed by their physician. The study measures oxygen consumption before and within one hour after fluid expansion using echocardiography combined with blood gas analyses from existing arterial and central venous lines. No additional invasive tests or blood draws are performed, and data such as hemodynamic and clinical information are collected from routine monitoring and medical records. Participants will undergo assessments at baseline and shortly after fluid expansion, including blood gas tests and echocardiography to measure cardiac output and oxygen content differences. The main measure is the diagnostic accuracy of the Pv-aCO2/CavO2 ratio in predicting metabolic fluid responsiveness. Secondary analyses include other blood markers, tissue oxygen saturation changes, and correlations with clinical profiles. Safety monitoring is inherent in standard care, and the study is expected to enroll 110 children with a follow-up period as specified by clinical practice.

Metabolic Fluid Responsiveness in Children