Actively Recruiting
Metabolic Fluid Responsiveness in Children
Led by University Hospital, Bordeaux · Updated on 2025-12-01
110
Participants Needed
8
Research Sites
108 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The investigators aim to validate markers of metabolic fluid-responsiveness in children with acute circulatory failure following cardiac surgery. This would allow physicians to identify which patient could benefit the most from fluid expansion, thus avoiding useless and potentially dangerous fluid expansions that could lead to fluid overload. To this end, The investigators will evaluate the diagnostic accuracy of the ratio of central venous to arterial carbon dioxide tension (Pv-aCO2) to arteriovenous oxygen content (CavO2), a simple biological marker of anaerobic metabolism, for the diagnosis of metabolic fluid responsiveness defined as a significant increase in oxygen consumption (VO2) after fluid expansion.
CONDITIONS
Official Title
Metabolic Fluid Responsiveness in Children
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age less than or equal to 15 years old
- Hospitalization in a pediatric intensive care unit after cardiac surgery
- Prescription by the attending physician of a fluid expansion of 10ml/kg
- Prescription of arterial and venous blood gas before and after the volume expansion to help manage acute circulatory failure
- Patient implanted with a functioning arterial line
- Patient implanted with a functioning central venous line in the superior vena cava territory
You will not qualify if you...
- Patient less than 37 weeks' corrected gestational age
- Hemodynamic instability making the delay necessary for any test dangerous
- Supine position contraindicated or deleterious
- Impairment of echocardiographic acoustic window or restless patient making ultrasonography impossible
- Opposition to participate expressed by the patient or by a parent or legal guardian
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 8 locations
1
Hôpital Louis Pradel - Hospices Civils de Lyon
Bron, France, France, 69500
Actively Recruiting
2
Hôpital Jeanne de Flandre - CHU de Lille
Lille, France, France, 59000
Actively Recruiting
3
Hôpital de la Timone - Assistance Publique - Hôpitaux de Marseille
Marseille, France, France, 13385
Not Yet Recruiting
4
Hôpital mère-enfant - CHU de Nantes
Nantes, France, France, 44093
Actively Recruiting
5
Hôpital Necker-Enfants Malades - Assistance Publique - Hôpitaux de Paris
Paris, France, France, 75015
Actively Recruiting
6
Hôpital Cardiologique Haut Lévêque - CHU de Bordeaux
Pessac, France, France, 33604
Actively Recruiting
7
Hôpital des enfants - CHU de Toulouse
Toulouse, France, France, 31300
Not Yet Recruiting
8
Hôpital Felix Guyon - CHU de la Réunion
Saint-Denis, La Réunion, France, 97400
Actively Recruiting
Research Team
J
Julin GOTCHAC, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here