Study of Metabolic and Functional Changes Related to Aging in Healthy and Diseased Adults

What this Trial Is About

Researchers are investigating the metabolic changes and functional consequences associated with aging in adults aged 50 and older. The study aims to understand how aging affects physical and cognitive functions, as well as overall well-being, by examining the metabolic profiles linked to disorders that may impair these abilities. This observational study focuses on the variability in aging experiences, including healthy longevity and age-related decline, to better understand pathways that contribute to aging-related disorders. Participants will undergo a series of assessments including stable tracer infusions that track amino acid and other metabolic pathways in the body. The study involves a screening visit to measure body weight, composition by DXA scan, height, and vital signs. On study days, participants may receive combinations of stable tracer infusions with blood draws, alongside cognitive and muscle performance testing to evaluate metabolic and functional changes. During the study, participants will be evaluated on whole-body metabolism including protein, amino acid, glucose, and fat metabolism. Additional assessments include mood, depression, anxiety, physical activity, sleep quality, nutrition, cognitive abilities, muscle strength, balance, respiratory strength, and gut health. Outcome measures focus on age-related changes across these domains, with data collected at baseline and during metabolic testing sessions lasting approximately two hours. Participants health and safety will be monitored throughout the study duration, which is expected to continue until September 2026.

Metabolic and Functional Consequences of Aging in Health and Disease