Pilot Study on How Metabolism and Genetics Affect Body Changes After Weight Loss Surgery

What this Trial Is About

This research aims to understand the behavioral, biological, and genetic factors that affect the success of weight loss surgery and how it impacts muscle mass. It focuses on patients undergoing bariatric surgery, who may experience loss of muscle and strength as well as weight regain, which can affect their quality of life and mobility. The study includes adults aged 18 to 65 years scheduled for bariatric surgery. Participants will be bariatric surgery patients undergoing either sleeve gastrectomy or gastric bypass surgery. The study monitors patients before surgery and for one year afterward. Data collected includes eating habits, hand grip strength, and changes in fat, muscle, and body weight. For those having a routine endoscopy before surgery, a small gut tissue sample will be taken to study gene activity. During the study, participants will have assessments at baseline and two additional times over the year after surgery. These include body composition, dietary protein intake, body weight, handgrip strength, and energy intake measurements. The study also explores gene expression from gut tissue collected pre-operatively. The total participation lasts about one year, with regular evaluations to track changes and outcomes.

The Metabolic and Genetic Drivers of Body Composition Changes Following Weight Loss Surgery