Actively Recruiting
Metabolic Heterogeneity Underlying Hypertriglyceridemia: Hepatic Triglyceride Biosynthesis in Humans With Different Insulin Resistance Phenotypes
Led by Yale University · Updated on 2026-01-27
40
Participants Needed
1
Research Sites
132 weeks
Total Duration
On this page
Sponsors
Y
Yale University
Lead Sponsor
A
Amsterdam UMC
Collaborating Sponsor
AI-Summary
What this Trial Is About
The focus of this cross-sectional study is to determine the effects of tissue-specific (adipose tissue or muscle) vs global (combined) insulin resistance (IR) on hepatic triglyceride biosynthesis in humans, and to determine differential effects of an acute exercise intervention on hepatic triglyceride biosynthesis in these groups.
CONDITIONS
Official Title
Metabolic Heterogeneity Underlying Hypertriglyceridemia: Hepatic Triglyceride Biosynthesis in Humans With Different Insulin Resistance Phenotypes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ability to give informed consent
- Overweight, defined as BMI 25-30 kg/m2
- Modest hypertriglyceridemia, defined as fasting plasma triglycerides 1.5-3.0mM
- High risk of insulin resistance, defined as fasting plasma insulin >64pM
- Stable weight for at least 3 months prior to participation
You will not qualify if you...
- Active or chronic liver disease, kidney disease, congestive heart failure, unstable angina, history of acute cardiovascular events within 6 months of screening, history of seizures or syncope, or an active infection requiring antimicrobial therapy
- Use of insulin, thiazolidinediones, SGLT2 inhibitors, or sulfonylureas
- Use of fibrates, omega 3 (fish oil), niacin, or PCSK9 antagonists
- Use of systemic glucocorticoids within 60 days prior to participation
- Hematocrit less than 35%
- Pregnancy or breastfeeding
- Active tobacco use, excessive alcohol intake (more than 14 units per week), or history of drug abuse
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
AMC Amsterdam
Amsterdam, Netherlands
Actively Recruiting
Research Team
D
Daniel F Vatner, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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