Actively Recruiting
Metabolic Heterogeneity Underlying Hypertriglyceridemia: Hepatic Triglyceride Biosynthesis in Humans With Different Insulin Resistance Phenotypes
Led by Yale University · Updated on 2026-01-27
40
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
Y
Yale University
Lead Sponsor
A
Amsterdam UMC
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying how different types of insulin resistance affect the way the liver produces triglycerides in people with insulin resistance and hypertriglyceridemia. The study compares individuals with insulin resistance in both muscle and fat tissues to those with insulin resistance mainly in muscle tissue. It also evaluates how a short exercise session before a meal influences liver triglyceride production in these groups. Participants will undergo two main interventions: a standardized dinner to assess liver triglyceride production and a standardized dinner combined with short premeal exercise sessions. Insulin sensitivity in muscle and fat tissues, glucose tolerance, and the contribution of newly made fats (de novo lipogenesis) to liver triglycerides will be measured. Blood samples will be collected the morning after the dinner to measure these effects, with a washout period between two study visits. During the study, participants will have their insulin sensitivity and blood triglyceride levels tested using oral glucose tolerance tests and blood draws. Researchers will track changes in triglyceride production and insulin resistance at baseline and after exercise interventions. The study will last up to eight weeks, with blood tests and metabolic assessments conducted at two study visits to evaluate responses to the interventions.
CONDITIONS
Brief Title
Metabolic Heterogeneity Underlying Hypertriglyceridemia: Hepatic Triglyceride Biosynthesis in Humans With Different Insulin Resistance Phenotypes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ability to give informed consent
- Overweight, defined as BMI 25-30 kg/m2
- Modest hypertriglyceridemia, defined as fasting plasma triglycerides 1.5-3.0 mM
- High risk of insulin resistance, defined as fasting plasma insulin >64 pM
- Stable weight for at least 3 months prior to participation
- Age between 18 and 65 years
You will not qualify if you...
- Active or chronic liver disease, kidney disease, congestive heart failure, unstable angina, history of acute cardiovascular events within 6 months of screening, history of seizures or syncope, or an active infection requiring antimicrobial therapy
- Use of insulin, thiazolidinediones, SGLT2 inhibitors, or sulfonylureas
- Use of fibrates, omega 3 (fish oil), niacin, or PCSK9 antagonists
- Use of systemic glucocorticoids within 60 days prior to participation
- Hematocrit less than 35%
- Pregnancy or breastfeeding
- Active tobacco use, excessive alcohol intake (>14 units per week), or history of drug abuse
AI-Screening
AI-Powered Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 8 weeks
Participants undergo two crossover interventions to assess de novo lipogenesis (DNL): one with a standardized dinner and one with premeal exercise followed by a standardized dinner. Glucose tolerance and insulin sensitivity evaluations occur prior to interventions.
2 study visits, each including ingestion of deuterated water prior to dinner and blood draw the following morning
Trial Site Locations
Total: 1 location
1
AMC Amsterdam
Amsterdam, Netherlands
Actively Recruiting
Research Team
D
Daniel F Vatner, MD, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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