Study of How Different Types of Insulin Resistance Affect Liver Fat Production and Response to Premeal Exercise in Adults with High Triglycerides

What this Trial Is About

Researchers are studying how different types of insulin resistance affect the way the liver produces triglycerides in people with insulin resistance and hypertriglyceridemia. The study compares individuals with insulin resistance in both muscle and fat tissues to those with insulin resistance mainly in muscle tissue. It also evaluates how a short exercise session before a meal influences liver triglyceride production in these groups. Participants will undergo two main interventions a standardized dinner to assess liver triglyceride production and a standardized dinner combined with short premeal exercise sessions. Insulin sensitivity in muscle and fat tissues, glucose tolerance, and the contribution of newly made fats de novo lipogenesis to liver triglycerides will be measured. Blood samples will be collected the morning after the dinner to measure these effects, with a washout period between two study visits. During the study, participants will have their insulin sensitivity and blood triglyceride levels tested using oral glucose tolerance tests and blood draws. Researchers will track changes in triglyceride production and insulin resistance at baseline and after exercise interventions. The study will last up to eight weeks, with blood tests and metabolic assessments conducted at two study visits to evaluate responses to the interventions.

Metabolic Heterogeneity Underlying Hypertriglyceridemia: Hepatic Triglyceride Biosynthesis in Humans With Different Insulin Resistance Phenotypes