Actively Recruiting
Metabolic Inflexibility is Related to Elevated Muscle Anaerobic Glycolysis
Led by East Carolina University · Updated on 2025-08-07
100
Participants Needed
1
Research Sites
299 weeks
Total Duration
On this page
Sponsors
E
East Carolina University
Lead Sponsor
D
Duke University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The focus of this proposal is on overweight (25\>BMI\<30 kg/m2) subjects, as these individuals exhibit a high risk of becoming obese and/or developing metabolic diseases. We hypothesize that in some overweight individuals there is a "metabolic program" in skeletal muscle which predisposes them to the development of obesity. Findings may lead to clinical screening tools for determining risk for obesity in non-obese individuals and targeting this group for prevention.
CONDITIONS
Official Title
Metabolic Inflexibility is Related to Elevated Muscle Anaerobic Glycolysis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 50 years
- Body mass index (BMI) between 25 and 30 kg/m2 or greater than 40 kg/m2
- Resting/fasting plasma lactate levels in the top or bottom 25 percentiles
You will not qualify if you...
- Pregnancy
- Mental disability
- Prisoner status
- Smoking
- Heart disease
- Type 1 or type 2 diabetes
- Endocrine disease
- Hypertension
- Musculoskeletal disease
- Peripheral occlusion
- Hepatic disease
- Weight fluctuations exceeding 3% in the previous 12 months
- Use of medications that alter carbohydrate metabolism
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
East Carolina University
Greenville, North Carolina, United States, 27834
Actively Recruiting
Research Team
T
Terry Jones, PhD
CONTACT
N
Nicholas Broskey, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here