Metabolic Phenotyping and Follow-Up of Patients With and Without Diabetes Mellitus After New Onset of ST-Segment Elevation Myocardial Infarction (STEMI) (DISTEMI Study)

What this Trial Is About

Researchers are studying people aged 18 to 80 who have recently experienced a specific type of heart attack called ST-segment elevation myocardial infarction (STEMI). The study compares those with diabetes, prediabetes, and normal blood sugar levels to understand their clinical, metabolic, immune, and vascular characteristics. It aims to explore how heart muscle changes relate to these metabolic profiles and to improve risk assessments and treatments tailored to individual patient profiles. Participants are grouped based on their glucose metabolism: those with diabetes (type 1 or type 2), those with normal glucose tolerance, and those with impaired glucose metabolism or prediabetes. The study involves detailed examinations at the start and one year after the heart attack to monitor changes in heart function, insulin sensitivity, fat distribution, liver condition, energy metabolism, and other metabolic factors. During the study, participants undergo various assessments including scans and tests to track heart and liver changes, insulin and energy metabolism, and the occurrence of additional cardiovascular complications. The main outcome measured is the change in cardiac function over one year. Researchers also monitor other metabolic changes and the development of diabetes or its complications. Participation lasts for one year, with careful follow-up to assess health progress and disease evolution.

Metabolic Phenotyping and Follow-Up of Patients With and Without Diabetes After New Onset of STEMI