Actively Recruiting
Metabolic Profiling of Immune Responses in Immune-mediated Diseases
Led by National Institute of Allergy and Infectious Diseases (NIAID) · Updated on 2026-04-08
300
Participants Needed
1
Research Sites
307 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: The immune system is the part of the body that fights infection. Some people have immune deficiencies that cause skin rashes, make them get sick often with infections, or make it difficult for their skin to heal. Researchers want to learn more to better treat conditions that affect immune response. Objective: To learn about how the immune system and skin healing are related to each other. Eligibility: People ages 18-75 with primary immune deficiency, eczema, or psoriasis. Healthy volunteers are also needed. Design: Participants will be screened with a medical and medicine history and a physical exam. They may take a pregnancy test. Participants will discuss the medicines or supplements they take as well as skin products they use, such as soaps and lotions. Participants will have up to 4 skin biopsies taken from the forearm. A needle will inject an anesthetic into the skin where the biopsy will be done. A sharp tool that looks like a tiny cookie cutter will be used to remove a round plug of skin a bit smaller than the tip of a pencil. Participants will give at least 1 blood sample. Participants may have optional skin swab collection. A cotton swab will be used to swab the skin on the arm. Participants may have optional skin tape collection. A sticky strip of tape will be placed on the arm and then removed. Participants may give leftover samples taken as part of their regular medical care. Participation will last for about 4 days. Participants will have 2 visits that each last about 1 hour. They may be asked to repeat the study in the future.
CONDITIONS
Official Title
Metabolic Profiling of Immune Responses in Immune-mediated Diseases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 75 years
- Diagnosis of primary immune deficiency confirmed by genetic testing or clinical history of frequent/severe infections
- Physician-diagnosed psoriasis
- Physician-diagnosed atopic dermatitis
- Healthy volunteers without immune defects, psoriasis, or atopic dermatitis
- Willing to allow storage of blood, biopsy tissue, cultures, and other samples for future research
- Able to provide informed consent
You will not qualify if you...
- Use of anticoagulant or anti-platelet therapy (other than aspirin or NSAIDs) within the past 3 months
- Use of immunomodulatory drugs such as chemotherapy or steroids within the past 3 months unless approved by the principal investigator
- History of keloid formation
- Pregnancy, breastfeeding, or lactating
- Any condition that the investigator believes makes participation unsafe
- Participants must notify study staff if co-enrolled in other studies
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
J
Jodi L Blake, R.N.
CONTACT
I
Ian A Myles, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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