The clinical pharmacokinetics of pyrazinamide in HIV-infected persons with tuberculosis.
David C Perlman, Yoninah Segal, Susan Rosenkranz...
https://pubmed.ncbi.nlm.nih.gov/14765350Completed
Phase Not Applicable
Age: 13Years +
All Genders
ID00000950
Pharmacokinetics of Antituberculosis Agents in HIV-Infected Persons With Tuberculosis
Led by National Institute of Allergy and Infectious Diseases (NIAID) · Updated on 2011-03-02
50
Participants Needed
13
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to determine if a relationship exists between the level of antituberculosis drugs (isoniazid, rifampin, ethambutol, and pyrazinamide) in the blood and the outcome of HIV-positive patients with tuberculosis. This study also evaluates how these drugs are absorbed and metabolized in the body.
CONDITIONS
Official Title
Metabolism of Antituberculosis Drugs in HIV-Infected Persons With Tuberculosis
Who Can Participate
Age: 13Years +
All Genders
Eligibility Criteria
You may qualify if you...
Inclusion Criteria
You may be eligible for this study if you:
- Are HIV-positive and have tuberculosis.
- Are 13 years of age or older.
- Have written, informed consent of parent or guardian if you are under 18 years of age.
- Agree to practice abstinence or use barrier methods of birth control during the study.
Exclusion Criteria
You will not be eligible for this study if you:
- Have any other disorder or condition which might cause study treatment to be undesirable.
- Are pregnant.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Trial Site Locations
Total: 13 locations
1
Univ of Southern California / LA County USC Med Ctr
Los Angeles, California, United States, 900331079
Status Unknown
2
Harbor UCLA Med Ctr
Torrance, California, United States, 90502
Status Unknown
3
University of Miami (Pediatric)
Miami, Florida, United States, 33136
Status Unknown
4
Emory Univ
Atlanta, Georgia, United States, 30308
Status Unknown
5
Queens Med Ctr
Honolulu, Hawaii, United States, 96816
Status Unknown
6
Univ of Hawaii
Honolulu, Hawaii, United States, 96816
Status Unknown
7
Tulane Univ School of Medicine
New Orleans, Louisiana, United States, 70112
Status Unknown
8
SUNY / Health Sciences Ctr at Brooklyn
Brooklyn, New York, United States, 112032098
Status Unknown
9
Beth Israel Med Ctr
New York, New York, United States, 10003
Status Unknown
10
St Vincent's Hosp / Mem Sloan-Kettering Cancer Ctr
New York, New York, United States, 10021
Status Unknown
11
Mount Sinai Med Ctr
New York, New York, United States, 10029
Status Unknown
12
MetroHealth Med Ctr
Cleveland, Ohio, United States, 441091998
Status Unknown
13
Univ of Pennsylvania at Philadelphia
Philadelphia, Pennsylvania, United States, 19104
Status Unknown
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How is the study designed?
Study Type
INTERVENTIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
TREATMENT
Number of Arms
0
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