Actively Recruiting
Metabolism, Circadian Rhythms and Ovarian Function
Led by University Hospital, Lille · Updated on 2025-12-26
50
Participants Needed
1
Research Sites
222 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Chemotherapy for cancer, due to its gonadotoxicity, can lead to impaired female fertility, resulting in the occurrence of transient or prolonged chemo-induced amenorrhea (CIA). According to recent data from the National Cancer Institute, 11.9% of women under the age of 40 diagnosed with cancer have been offered a fertility evaluation within five years of diagnosis. Predicting the risk and especially the duration of the CIA remains difficult. Known factors predicting a rapid return of menstruation are a young age at diagnosis, a low gonadotoxic treatment (absence of alkylating agents) and a high pre-chemotherapy blood level of AMH reflecting a large pool of growing follicles. A body mass index (BMI) ≥ 25 kg / m² could also be a positive predictor, but this remains debated. The objective of this project is to assess the impact of metabolism and energy reserves, physical activity and the chronotype on the recovery of ovarian function in patients with breast cancer who have developed CIA
CONDITIONS
Official Title
Metabolism, Circadian Rhythms and Ovarian Function
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women with chemotherapy-induced amenorrhea who requested post-cancer fertility follow-up at the University Hospital of Lille, France
- Women aged between 25 and 35 years at the time of inclusion
- Women treated with chemotherapy protocol FEC 100 (3 cycles) plus docetaxel (3 cycles)
You will not qualify if you...
- Women without chemotherapy-induced amenorrhea
- Women who refuse to participate in the study
- Women older than 35 years at the time of inclusion
- Women who received a chemotherapy protocol other than FEC 100 plus docetaxel
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Hop Jeanne de Flandre Chu Lille
Lille, France
Actively Recruiting
Research Team
P
Pascal PIGNY, MD,PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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