Study of Metabolomic and Immune Profiles to Understand and Predict Pancreatic Fistulas After Pancreatoduodenectomy Surgery

What this Trial Is About

Researchers are investigating complications that can occur after pancreatoduodenectomy, a common surgery for treating pancreatic lesions. The study aims to identify biomarkers and risk factors for pancreatic fistula PF and postpancreatectomy acute pancreatitis PPAP by analyzing the bodys metabolites and immune status. This observational research seeks to improve understanding of these complications to help develop preventive strategies. Adult patients scheduled for elective pancreatoduodenectomy will participate without changes to their usual surgical care. During surgery, a small piece of non-tumoral pancreatic tissue will be collected and frozen for metabolomic analysis. Additionally, four blood samples will be taken at specific times before surgery, and then 7 days, 1 month, and 3 months after surgery to assess the immune response. Participants will be monitored during hospitalization and for up to 3 months afterward to track the occurrence of significant pancreatic fistulas or acute pancreatitis after surgery. Researchers will evaluate blood and tissue samples to identify predictive markers linked to these complications. The study involves regular assessments and follow-ups to gather detailed information on post-surgical outcomes and immune changes over time.

METabolomic and Immune PROfiling in the Development of Pancreatic Fistulas After cepHalic duodEnopancreatectomy