Actively Recruiting
Metabolomic and Lipidomic Analysis Predicts Immunotherapy-related Adverse Events in Gastric Cancer Patients
Led by Qinghai Red Cross Hospital · Updated on 2025-04-08
100
Participants Needed
1
Research Sites
122 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study comprehensively examines metabolic and lipidomic dynamics in gastric cancer patients initiating PD-1/PD-L1 inhibitor therapy, employing a longitudinal design with pre- and post-treatment patients. The primary objectives include identifying irAE-associated metabolic and lipid biomarkers, developing predictive risk models, and evaluating the prognostic value of these molecular profiles. The findings are expected to contribute significantly to personalized treatment strategies and improved clinical decision-making in immunooncology.
CONDITIONS
Official Title
Metabolomic and Lipidomic Analysis Predicts Immunotherapy-related Adverse Events in Gastric Cancer Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- ECOG Performance Status of 0 to 2
- Gastric cancer confirmed by histology or cytology
- No prior treatment with PD-1/PD-L1 inhibitors
- Expected survival of at least 3 months
- Willingness and ability to adhere to treatment, follow-up, and research protocols, including signing informed consent
You will not qualify if you...
- Unable to obtain sufficient tissue material to diagnose gastric cancer
- Refusal to receive PD-1/PD-L1 inhibitor treatment
- No available baseline plasma samples before immunotherapy
- Presence of autoimmune diseases
- Severe diseases affecting heart, lungs, thyroid, or other organs at baseline
- Severe abnormalities in liver and kidney functions, pancreatic enzymes, or other indicators at baseline
- Any condition that may harm the participant or prevent adherence to study requirements
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Qinghai Red Cross Hospital
Xining, Qinghai, China, 810000
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here