Actively Recruiting
Metabolomics and Biomarker Research on How Preoperative Sleep Disorders Affect Outcomes After Adult Cardiac Surgery
Led by Yan Fuxia · Updated on 2026-05-14
144
Participants Needed
1
Research Sites
N/A
Total Duration
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AI-Summary
What this Trial Is About
Researchers are studying how preoperative sleep disorders affect outcomes after adult cardiac surgery. This observational study aims to understand the changes in metabolism and other biological markers during the perioperative period. By exploring how sleep problems before surgery influence recovery and complications like delirium, the study hopes to provide insights into the mechanisms behind adverse postoperative results in adult cardiac surgery patients. The study involves collecting blood and fecal samples from adult patients scheduled for elective cardiac surgery who either have or do not have preoperative sleep disorders. Researchers will analyze these samples to observe differences in plasma metabolic substances, inflammatory markers, nerve injury markers, oxidative stress levels, and intestinal flora before and shortly after surgery. There is no drug or treatment intervention in this observational study. Participants will be monitored around the time of surgery, with sample collection and clinical outcome tracking including delirium incidence, cognitive function, mechanical ventilation time, ICU stay, hospital stay, and severe cardiovascular events. The primary outcome is the change in plasma metabolic substances within 24 hours before and after the operation. Secondary outcomes include inflammatory, nerve injury, oxidative stress markers, and intestinal flora characteristics before surgery. The study will continue through the postoperative period, providing comprehensive data on the impact of sleep disorders on surgical recovery.
CONDITIONS
Brief Title
Metabolomics and Biomarker Research on the Mechanism of Preoperative Sleep Disorders Affecting Postoperative Outcomes in Cardiac Surgery Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Scheduled for elective cardiac surgery
You will not qualify if you...
- History of neurosurgery or neurological diseases such as cerebral hemorrhage, cerebral infarction, delirium, or dementia
- History of mental disorders
- Heavy alcohol consumption
- American Society of Anesthesiologists (ASA) classification level IV or above
- Severe liver dysfunction (Child-Pugh C grade) or renal dysfunction (chronic kidney disease stage 3-4)
- Unable to communicate due to hearing or language problems, or refusal to sign informed consent form
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 2 days (24 hours before and 24 hours after surgery)
Participants undergo assessments related to metabolic substances, inflammatory markers, nerve injury markers, oxidative stress markers, and intestinal flora before and after cardiac surgery.
2 visits (one before surgery and one after surgery)
Duration - Up to surgery date and immediate postoperative period
Participants who undergo routine cardiac surgery are observed for postoperative outcomes related to preoperative sleep disorders.
Visit schedule as per routine care
Trial Site Locations
Total: 1 location
1
Fuwai Hospital
Beijing, Beijing Municipality, China, 100037
Actively Recruiting
Research Team
F
Fuxia Yan, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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