Actively Recruiting
Metabolomics During ElectroConvulsivoTherapy
Led by Hôpital le Vinatier · Updated on 2025-07-24
50
Participants Needed
1
Research Sites
135 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Investigators will measure the variation of blood Metabolome through 1H NMR at several time points during the course of electroconvulsivetherapy in patients with a major depressive episode. Patients with a major depressive disorder or a bipolar disorder and a current major depressive episode will be included in this study. Investigators hypothesized that Metabolome could be a source to predict response during ECT and to help understanding underlying biological mechanisms.
CONDITIONS
Official Title
Metabolomics During ElectroConvulsivoTherapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Major depressive episode according to DSM-5 criteria
- Diagnosis of major depressive disorder or bipolar disorder
- MADRS score greater than 22
- Given written, free, and informed consent
- Not under protective measures
- Resistance to treatment defined as failure of 2 antidepressants at effective doses for at least 6 weeks
- Currently experiencing a major depressive episode with indication for ECT treatment
You will not qualify if you...
- Unable to give admissible consent or refusal to participate
- Deprived of liberty by judicial or administrative decision
- At particular risk contraindicating ECT treatment
- Diagnosed with schizophrenia spectrum disorders or persistent delusional disorder as per DSM-5 Criterion D
- Suffering from neurological disorders (e.g., multiple sclerosis, epilepsy, encephalitis) or neurodegenerative disorders (e.g., Parkinson's, Alzheimer's) per DSM-5 Criterion C
- Having acute or chronic systemic inflammatory disease requiring immunomodulatory or suppressive treatment, or recurrent inflammatory disease that may mimic depressive episode
AI-Screening
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Trial Site Locations
Total: 1 location
1
Centre Hospitalier le Vinatier
Bron, France, 69678
Actively Recruiting
Research Team
C
COSTEMALE-LACOSTE Jean-François, PH
CONTACT
S
SARTELET Lydie
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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