Actively Recruiting
Metformin as an add-on or Monotherapy in Treatment of Aging People With Multiple Sclerosis (MS)
Led by State University of New York at Buffalo · Updated on 2025-11-21
30
Participants Needed
1
Research Sites
87 weeks
Total Duration
On this page
Sponsors
S
State University of New York at Buffalo
Lead Sponsor
N
National Center for Advancing Translational Sciences (NCATS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of the study is to learn about treating older people with multiple sclerosis (MS) with metformin. Metformin may be used as a single therapy or as an add-on therapy. The investigators want to learn: * The safety and tolerability of metformin extended release (1500 mg/day) as a single therapy or as an add-on therapy in older people with MS compared to placebo * How well metformin protects the nervous system against injury compared with placebo measured by brain MRI over a 9 month treatment period * The effect of metformin to protect brain tissue from age and MS related injury when compared to the placebo group over a 9 month treatment period
CONDITIONS
Official Title
Metformin as an add-on or Monotherapy in Treatment of Aging People With Multiple Sclerosis (MS)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 55 and 75 years old
- Diagnosis of multiple sclerosis based on the latest McDonald criteria
- No relapses or MRI activity related to MS in the last 2 years
- Expanded Disability Status Scale (EDSS) score less than 7.0
You will not qualify if you...
- Unable to undergo MRI scans
- Unable to participate in the study during the study period
- Diabetes or uncontrolled cardiovascular disease
- Unable to give consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UBMD Neurolgy
Buffalo, New York, United States, 14203
Actively Recruiting
Research Team
K
Kara Patrick
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here