Actively Recruiting
Metformin as Added on Therapy in Patients With Ulcerative Colitis
Led by Tanta University · Updated on 2025-03-04
46
Participants Needed
1
Research Sites
218 weeks
Total Duration
On this page
Sponsors
T
Tanta University
Lead Sponsor
P
Principal Investigator Mostafa Mahmoud Bahaa El-Dien Pharmacy Practice Department- Horus University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Ulcerative colitis (UC) is a chronic inflammatory bowel disease that is marked by increased intestinal motility and bloody diarrhea. The clinical value of existing therapeutic strategies of UC, including glucocorticoids, anti-tumor necrosis factor α (TNF-α), mesalamine, and thiopurines is still limited. Therefore, the discovery of new therapeutic approaches is essential to improve the effectiveness of the treatment.Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a conserved fuel-sensing enzyme that plays an important role in the regulation of cellular metabolism where it increases glucose and fatty acids uptake and activates the oxidation process to improve the cellular energy utilization
CONDITIONS
Official Title
Metformin as Added on Therapy in Patients With Ulcerative Colitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Both males and females are eligible
- Negative pregnancy test and use of effective contraception
- Diagnosis of mild to moderate ulcerative colitis confirmed by endoscopy
You will not qualify if you...
- Currently breastfeeding
- Significant liver or kidney function abnormalities
- Diagnosis of diabetes
- Diagnosis of colorectal cancer
- Severe ulcerative colitis
- Use of rectal or systemic steroids
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Faculty of Medicine, Mansoura University
Al Mansurah, Egypt, 7650001
Actively Recruiting
Research Team
M
Mostafa Bahaa, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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