Actively Recruiting
Metformin IN Asthma for Overweight and Obese Individuals (MINA)
Led by Johns Hopkins University · Updated on 2026-01-16
100
Participants Needed
2
Research Sites
211 weeks
Total Duration
On this page
Sponsors
J
Johns Hopkins University
Lead Sponsor
B
Baylor College of Medicine
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a randomized clinical trial of metformin among overweight or obese adults with not well-controlled asthma despite maintenance inhaler therapy.
CONDITIONS
Official Title
Metformin IN Asthma for Overweight and Obese Individuals (MINA)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Physician-diagnosed asthma on maintenance therapy
- Not well-controlled asthma (ACT score <20, or at least one asthma exacerbation requiring corticosteroids in the prior 12 months)
- Overweight or obesity: Body mass index ≥25kg/m2
- Adult: Age ≥18
You will not qualify if you...
- Currently pregnant, expect to become pregnant in the next 6 months or are currently breastfeeding
- Major cardiovascular disease: heart failure, heart attack or stroke within the last 6 months
- Other chronic lung disease, inclusive of chronic obstructive pulmonary disease, bronchiectasis, interstitial lung disease, pulmonary fibrosis
- Active smoking or former smoker with ≥20 pack-year smoking history
- Chronic kidney disease: estimated glomerular filtration rate ≤60 mL/min/1.73 m2
- Heavy alcohol use: in a typical week, 8 or more drinks for a woman or 15 or more drinks for a man
- Liver disease: elevation in aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 2x the upper limit of normal or prior diagnosis of liver disease
- Anemia: hemoglobin < 13 g/dl in males and hemoglobin < 11 g/dl in females
- Taking Glucagon Like Peptide 1(GLP-1) medications for weight loss
- Diabetes (Hemoglobin A1C ≥ 6.5% or taking metformin or other medications used to treat diabetes)
- Participation in any other clinical trial (observational studies are permitted)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Johns Hopkins University
Baltimore, Maryland, United States, 21224
Actively Recruiting
2
Baylor College of Medicine
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
R
Rachelle Koehl, M.S.
CONTACT
M
Meredith C McCormack, M.D., M.H.S.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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