Actively Recruiting
Metformin for People With CFRD on CFTR Modulator Therapy to Improve Ion Channel Function
Led by University of Kansas Medical Center · Updated on 2026-04-15
30
Participants Needed
1
Research Sites
334 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to assess the efficacy of metformin to improve airway ion channel function in those with CF-related diabetes (CFRD)
CONDITIONS
Official Title
Metformin for People With CFRD on CFTR Modulator Therapy to Improve Ion Channel Function
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age over 18 years with prior diagnosis of cystic fibrosis
- Use of ivacaftor, elexacaftor/tezacaftor/ivacaftor, or vanzacaftor/tezacaftor/deutivacaftor for at least 30 days before starting
- Diagnosis of cystic fibrosis-related diabetes with ongoing glucose intolerance at least 6 months after starting modulator therapy, confirmed by insulin use, hemoglobin A1C over 6.5%, fasting glucose over 126 mg/dl, or non-fasting glucose over 200 mg/dl
You will not qualify if you...
- Prior lung or liver transplant
- Use of supplemental oxygen
- Body mass index under 18
- Cystic fibrosis lung flare requiring hospitalization or IV antibiotics within last 30 days
- Use of systemic corticosteroids or regular non-steroidal anti-inflammatory drugs in last 30 days
- Cardiac, kidney (creatinine clearance under 45 mL/min), neurological, psychiatric, endocrine, or cancer conditions interfering with study
- Elevated liver enzymes or bilirubin above specified limits
- Taking medications that interact with metformin
- Vitamin B12 deficiency
- Pregnancy or breastfeeding
- Inability or unwillingness to use approved birth control during study (for women of childbearing age)
- Use of strong CYP inducers or moderate to strong CYP inhibitors
- Any severe or acute or chronic condition or lab abnormality increasing trial risk or inappropriate for enrollment
- Participation in another interventional trial affecting the primary outcome
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Kansas Medical Center
Kansas City, Kansas, United States, 66160
Actively Recruiting
Research Team
M
Matthias A Salathe, M.D.
CONTACT
C
Carolina Aguiar
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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