Actively Recruiting
Metformin for Premature Infants With Bronchopulmonary Dysplasia
Led by Medical College of Wisconsin · Updated on 2026-01-26
40
Participants Needed
1
Research Sites
245 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The overall objective of this study is to investigate the role of metformin in decreasing lung injury and promoting lung growth in premature infants. There are two phases to this pilot study. For Phase 0, the goal is to investigate the safety and tolerance of oral metformin in premature who have been diagnosed with bronchopulmonary dysplasia (BPD) at 36-44 weeks gestation. For Phase 1, the goal is to investigate metformin safety and tolerance in extremely premature infants who are 7-30 days old who have an increased risk of BPD. The main questions it aims to answer are: * how well do older premature infants tolerate metformin? * how well do younger premature infants tolerate metformin?
CONDITIONS
Official Title
Metformin for Premature Infants With Bronchopulmonary Dysplasia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Birth gestational age of less than 29 weeks and postnatal age between 8 and 22 weeks with a diagnosis of BPD at 36 weeks postnatal age (Phase 0)
- Birth gestational age of less than 29 weeks, requiring mechanical ventilation or positive pressure support at 7 days postnatal age, and postnatal age between 7 and 30 days (Phase 1)
You will not qualify if you...
- Persistent hypoglycemia
- Lactic acidosis
- Feeding intolerance
- Renal or hepatic dysfunction
- Active infection
- Congenital anomalies that prevent feedings
- Infants whose parents have chosen palliative care
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Children's Wisconsin
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
Research Team
K
Kathleen Meskin, BSN, RN, CCRP
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
BASIC_SCIENCE
Number of Arms
9
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