Actively Recruiting
Metformin Safety and Efficacy in Osteoarthritis.
Led by Mostafa Bahaa · Updated on 2026-03-13
70
Participants Needed
1
Research Sites
198 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Knee osteoarthritis (OA) is a chronic, painful disease associated with considerable morbidity, costs and disability. It is estimated that over a third of people aged over 60 have radiographic knee OA2 and over 50% of these with knee OA will go on to have a total knee replacement in their lifetime. At present there are no licensed treatments that alter disease progress and management is primarily concerned with symptom control to retain or improve joint function, although a trial of strontium ranelate showed promising results.
CONDITIONS
Official Title
Metformin Safety and Efficacy in Osteoarthritis.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Primary osteoarthritis patients aged between 30 and 60 years
- X-ray confirmed Kellgren-Lawrence grade II or III severity primary tibiofemoral osteoarthritis according to American College of Rheumatology criteria
You will not qualify if you...
- Age less than 30 years or more than 60 years
- Active gastroduodenal disorders, liver or kidney impairment within 30 days before study drug
- Diagnosed with inflammatory arthritis, gout, or acute trauma of the knee, hip, or spine
- Osteoarthritis of the hip severe enough to affect knee function assessment
- Previous or ongoing treatment with oral SYSADOA, antidepressants, tranquillisers, antacids, or antibiotics
- Active cardiac lesion or hypertension
- Pregnant or planning pregnancy during the study
- Known hypersensitivity to study medications
- Persistent diarrhea or laxative use
- Severe gastrointestinal disorders, severe obesity, severe organ disease, or anemia (hemoglobin <10.0 g/dl or hematocrit <30%)
- Received corticosteroids by any route within 8 weeks before first dose
- Underwent joint lavage or arthroscopic procedures in the past 6 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Mostafa Bahaa
Damietta, New Damietta, Egypt, 34518
Actively Recruiting
Research Team
M
Mostafa Bahaa
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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