Actively Recruiting

Phase 2
Age: 20Years - 90Years
All Genders
NCT06826092

Metformin for the Treatment of mCRC Patients Undergoing FOLFIRI Plus Target Therapy

Led by Kaohsiung Medical University Chung-Ho Memorial Hospital · Updated on 2025-02-13

110

Participants Needed

1

Research Sites

165 weeks

Total Duration

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AI-Summary

What this Trial Is About

To investigate progression-free survival (PFS) in patients with metastatic colorectal cancer treated with chemotherapy FOLFIRI monotherapy or chemotherapy FOLFIRI combined with Metformin

CONDITIONS

Official Title

Metformin for the Treatment of mCRC Patients Undergoing FOLFIRI Plus Target Therapy

Who Can Participate

Age: 20Years - 90Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Aged between 20 and 90 years old
  • Diagnosed with metastatic colorectal cancer and scheduled to receive FOLFIRI chemotherapy
  • Female participants must not be pregnant, breastfeeding, or planning pregnancy during treatment and must use contraception
  • No major physiological diseases such as acute myocardial infarction, acute stroke, malignant hypertension, acute kidney failure, or acute liver failure
  • No allergies to the study drugs
  • Able to follow doctor's instructions for medication
  • Willing to sign informed consent
  • Blood sugar level above 80 mg/dL
Not Eligible

You will not qualify if you...

  • Does not meet the main inclusion criteria
  • Non-native speakers
  • Known allergy to Metformin or its components
  • Severe unstable diabetes (ketoacidosis)
  • Blood sugar level below 80 mg/dL
  • Heart failure or respiratory insufficiency
  • Inadequate hematopoietic function (hemoglobin < 9 g/dL, ANC < 1,500/mm3, platelet count < 100,000/mm3)
  • Inadequate organ function (total bilirubin > 2 times ULN, ALT or AST > 2.5 times ULN, creatinine > 1.5 times ULN)

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Chung-Ho Memorial Hospital, Kaohsiung Medical University:

Kaohsiung City, Taiwan, 807

Actively Recruiting

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How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

SUPPORTIVE_CARE

Number of Arms

2

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