Actively Recruiting
Methacholine Challenge Test in School Children With/Without Asthma RISKA
Led by Helsinki University Central Hospital · Updated on 2025-06-22
260
Participants Needed
1
Research Sites
160 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The study includes a pre-study telephone interview with healthy controls to assess their eligibility for participation. During the study visit, a background information form and an asthma questionnaire are completed. At the study visit, a methacholine challenge test measuring airway hyperresponsiveness and an exhaled nitric oxide measurement are performed. The effect of medication intensification in asthma patients is further assessed through a telephone interview 1-2 months after the medication adjustment.
CONDITIONS
Official Title
Methacholine Challenge Test in School Children With/Without Asthma RISKA
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy children aged 7 to 15 years, both sexes
- No asthma diagnosis during childhood for healthy controls
- No inhaled asthma medication during the past 2 years for healthy controls
- No wheezing or shortness of breath during the past 2 years for healthy controls
- Written informed consent from participant and guardian
- Children aged 7 to 15 years with physician-diagnosed asthma (ICD-10 J45.0/J45.1/J45.9)
- Inhaled corticosteroid treatment for at least 6 months
- Well-controlled asthma (c-ACT/ACT score 20 or higher) with no need to intensify medication, or poorly controlled asthma needing medication intensification
You will not qualify if you...
- Premature birth before 32 gestational weeks
- Other chronic cardiopulmonary or neurological conditions affecting airways (excluding asthma)
- Severe underlying illness such as malignancy
- Use of beta-blocker medication
- Active immunological disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
HUS Skin and Allergy Hospital
Helsinki, Finland, 00250
Actively Recruiting
Research Team
J
Janne Burman, PhD, MD
CONTACT
A
Anssi Koivuselkä, Nurse
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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