Actively Recruiting
Methadone Pharmacokinetics in End-stage Renal Disease
Led by Pontificia Universidad Catolica de Chile · Updated on 2024-05-10
20
Participants Needed
1
Research Sites
38 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to describe the influence of renal function on the pharmacokinetics of methadone used through an intravenous patient-controlled analgesia (IV-PCA) pump for the management of acute postoperative pain. After surgery the participants will use an IV-PCA of methadone and blood samples will be withdrawn to measure the plasmatic levels of it. The main question the study aims to answer is: • Is the pharmacokinetic of methadone used in an IV-PCA pump impaired in patients with chronic kidney disease?
CONDITIONS
Official Title
Methadone Pharmacokinetics in End-stage Renal Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with chronic kidney disease (CrCl 15-60 ml/min)
- Patients over 18 years old undergoing surgery requiring general anesthesia with subsequent use of intravenous methadone patient-controlled analgesia
- Hospital stay 2 48 hours
- Body mass index 18-35 kg/m2
You will not qualify if you...
- History of liver disease
- Need for dialysis (hemo or peritoneal dialysis)
- Use of home oxygen therapy
- American Society of Anesthesiologists (ASA) physical status IV-V
- Pregnancy
- Chronic opioid use
- Methadone allergy
- Prolonged QT interval
- Use of antiarrhythmics that prolong the QT interval
- Inability to understand the proper use of PCA
AI-Screening
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Trial Site Locations
Total: 1 location
1
Pontificia Universidad Católica de Chile
Santiago, Chile, 7550000
Actively Recruiting
Research Team
E
Eduardo Vega, MD
CONTACT
V
Victor Contreras, MSN
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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