Actively Recruiting
Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study
Led by The Cleveland Clinic · Updated on 2025-12-17
120
Participants Needed
1
Research Sites
150 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The investigators propose a randomized, triple-blinded (patients, investigators, outcomes assessors), placebo-controlled pilot feasibility trial (Methadone to End Narcotic Dependence, MEND trial) to assess the feasibility and safety of postoperative oral methadone in patients undergoing spine surgery and collect preliminary data to inform a larger clinical trial that will test the opioid-sparing effects of methadone at 3 months after spine surgery.
CONDITIONS
Official Title
Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult 18 years of age or older
- Scheduled for multilevel lumbar and/or thoracic spine fusion (primary or revision)
You will not qualify if you...
- Younger than 18 or older than 72 years of age
- Body Mass Index greater than 40
- Known allergy to methadone
- Pregnant females
- Non-English-speaking patients
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Actively Recruiting
Research Team
S
Stephanie Stoianoff, MBA
CONTACT
S
Sandra Durbin, CLPN, CCRP
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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