Evaluating Methadone to Reduce Pain and Opioid Use After Total Hip Replacement Surgery with Spinal Anesthesia

What this Trial Is About

Researchers are studying whether giving methadone during surgery can reduce pain and the need for other opioids after total hip replacement surgery performed with spinal anesthesia using mepivacaine. This phase 3 randomized, double-blind controlled trial aims to evaluate pain levels and opioid use after surgery in patients aged 18 to 75 years undergoing elective total hip arthroplasty. Participants will be randomly assigned to receive either methadone intravenously at a dose of 0.15 mgkg based on ideal body weight during surgery or no methadone. The study compares these two groups to assess differences in pain and opioid consumption after surgery. During the study, participants pain will be measured using a visual analog scale shortly after surgery and at multiple time points up to 72 hours postoperatively. Researchers will also track opioid use, time to first opioid rescue dose, incidence of nausea or vomiting, and quality of recovery within 24 hours after surgery. The total participation duration covers assessments during the immediate recovery period and up to 30 days for opioid use monitoring.

Methadone in THA for Post-op Pain and Opioid Reduction