Actively Recruiting
Methadone in TKA for Post-op Pain and Opioid Reduction
Led by Medical University of South Carolina · Updated on 2026-02-04
162
Participants Needed
1
Research Sites
53 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This randomized, double-blind controlled trial investigates whether intraoperative IV methadone (0.15 mg/kg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing elective total knee arthroplasty under spinal anesthesia with mepivacaine.
CONDITIONS
Official Title
Methadone in TKA for Post-op Pain and Opioid Reduction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ages 18-75 years of age
- Undergoing elective primary total knee arthroplasty with mepivacaine in the spinal anesthesia
You will not qualify if you...
- Allergy to methadone or mepivacaine
- Severe liver disease defined as Child's Pugh Class C
- End stage renal disease requiring dialysis
- Known diagnosis of prolonged QT syndrome
- Currently pregnant
- Unable to provide written, informed consent
- Non-English speaking
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Medical University of South Carolina
Charleston, South Carolina, United States, 29425
Actively Recruiting
Research Team
H
Haley Nitchie, MHA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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