Actively Recruiting
Methadone Versus Intrathecal Hydromorphone for Postoperative Pain Relief in Gynecologic Cancer Undergoing Surgery
Led by Mayo Clinic · Updated on 2026-03-04
140
Participants Needed
1
Research Sites
260 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This phase IV trial compares methadone versus hydromorphone given in the fluid-filled space between the thin layers of tissue that cover the brain and spinal cord (intrathecal) for postoperative pain relief in patients with gynecologic cancer undergo surgery. Methadone binds to opioid receptors in the central nervous system and is a long-acting opioid pain medication. Intrathecal hydromorphone works by changing the way the brain and nervous system respond to pain and is similar to an epidural. This trial may help researchers determine if methadone works as well as intrathecal hydromorphone for pain relief after surgery in patients with gynecologic cancer.
CONDITIONS
Official Title
Methadone Versus Intrathecal Hydromorphone for Postoperative Pain Relief in Gynecologic Cancer Undergoing Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Undergoing surgery with a laparotomy for gynecologic malignancy
- Planned inpatient admission greater than 24 hours
You will not qualify if you...
- Chronic pain requiring more than 20 morphine milligram equivalents of outpatient opioids
- Prolonged corrected QT interval (QTc) greater than 500 milliseconds
- Chronic kidney disease with estimated glomerular filtration rate less than 30 mL/min
- Documented cirrhosis
- Preoperative platelets less than 100
- Preoperative international normalized ratio greater than 1.1
- Inappropriate cessation of anticoagulation medications before surgery
- Intolerance to hydromorphone or methadone
- Contraindication to liposomal bupivacaine
- Subsequent surgeries after the main surgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
C
Clinical Trials Referral Office
CONTACT
K
Karen Ishitani, R.N.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here