Actively Recruiting
Study of Trorluzole as a Treatment for Methamphetamine Use Disorder in Adults Aged 18 to 55
Led by William Stoops · Updated on 2026-06-08
40
Participants Needed
1
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
Researchers are evaluating the effects of troriluzole, an investigational drug, on the influence of methamphetamine in people with methamphetamine use disorder. This human laboratory study is part of the Helping to End Addiction Long-term HEAL Initiative, aiming to better understand how troriluzole might affect the reinforcing properties of methamphetamine in this population. Participants will be randomly assigned to one of three groups daily oral placebo, daily oral troriluzole 140 mg, or daily oral troriluzole 280 mg. During experimental sessions, intravenous methamphetamine or placebo will be administered to assess the drugs effects while participants are admitted as inpatients for about one month. Participants will stay in the inpatient setting for approximately one month, during which they will undergo nine assessments of methamphetamines reinforcing effects. Researchers will monitor health through medical and psychiatric evaluations, ECG readings, urine drug tests, and careful observation for any side effects. The study aims to gather detailed information about how troriluzole impacts methamphetamine use and related behaviors.
CONDITIONS
Brief Title
Methamphetamine and Troriluzole
Research Team
W
William W Stoops, PhD
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