Comparing Methenamine and Antibiotics to Prevent Urinary Tract Infections After Mid-Urethral Sling Surgery in Women

What this Trial Is About

Stress urinary incontinence SUI affects a significant number of women, with synthetic polypropylene mid-urethral slings MUS being the standard treatment. However, post-operative urinary tract infections UTIs are common complications after MUS, occurring in up to 21-34% of cases. This study aims to evaluate whether methenamine, a urinary antiseptic, is as effective as antibiotic prophylaxis in preventing UTIs after MUS placement, addressing concerns over antibiotic resistance and treatment failures. Participants will be randomly assigned to receive either methenamine hippurate or antibiotic prophylaxis after their MUS procedure. The methenamine group will take 1g twice daily, while the antibiotic group will receive prophylaxis according to physician preference. The study focuses on the 6-week period following the surgery to monitor for UTIs and related adverse effects. During the trial, participants will be monitored for the incidence of UTIs within 6 weeks post-procedure, adverse effects, and any additional treatments needed for UTIs. Researchers will collect data on these outcomes to compare the two prophylactic strategies. The study is open to females aged 18 to 100 undergoing the MUS procedure, and participation includes follow-up visits and assessments within the 6-week timeframe.

Is Methenamine Prophylaxis for Urinary Tract Infection After Midurethral Sling as Effective as Antibiotic Prophylaxis?