Actively Recruiting
Methoxyflurane for IUD Insertion and Endometrial Biopsy
Led by Mount Sinai Hospital, Canada · Updated on 2025-07-30
174
Participants Needed
1
Research Sites
31 weeks
Total Duration
On this page
Sponsors
M
Mount Sinai Hospital, Canada
Lead Sponsor
M
Matthew Morton Research Award
Collaborating Sponsor
AI-Summary
What this Trial Is About
The aim of this study is to determine if 3ml of inhaled Methoxyflurane, in the form of a Penthrox inhaler, reduces pain during IUD insertion and/or endometrial biopsy. The proposed study is a double-blind, placebo-controlled RCT. Each participant will be randomly assigned to one of two arms: 1. Intervention (3ml of Methoxyflurane via a Penthrox inhaler) 2. Placebo (3ml of normal saline via an identical placebo Penthrox inhaler) The primary outcome is global pain score, which will be patient-reported by the 100 mm Visual Analogue Scale (VAS) 5-minutes following the procedure (endometrial biopsy or IUD insertion).
CONDITIONS
Official Title
Methoxyflurane for IUD Insertion and Endometrial Biopsy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female participants aged 18 to 65 years presenting for IUD insertion or endometrial biopsy
- Only nulliparous patients for IUD insertion
- English speaking participants
- Availability of a ride home after the appointment
You will not qualify if you...
- Use of pain medication other than NSAIDs or acetaminophen within past 24 hours
- Misoprostol use within 24 hours
- Currently breastfeeding
- Diagnosed chronic pain syndromes such as fibromyalgia or vaginismus
- Allergy to methoxyflurane
- Renal or liver disease
- Known or genetic susceptibility to malignant hyperthermia or severe adverse reactions in patient or relatives
- Baseline low vital signs: systolic blood pressure less than 100, diastolic less than 60, or pulse less than 60
- Previous unsuccessful office attempt at IUD insertion or endometrial biopsy by the same practitioner
- Clinically evident respiratory impairment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
OPG
Toronto, Ontario, Canada, M5G 1Z5
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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