Actively Recruiting
Metreleptin in Anorexia Nervosa
Led by Gabriella Milos · Updated on 2026-01-15
50
Participants Needed
1
Research Sites
117 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The treatment of anorexia nervosa often proves to be difficult. There are no drugs that work specifically for the treatment of anorexia nervosa. Experimental administration of metreleptin (synthetically produced leptin) to patients with anorexia nervosa has produced positive results. This study tests the effect of metreleptin in comparison with placebo, which could potentially make treatment easier. The aim of the study is to investigate whether treatment with metreleptin can help to reduce the symptoms of anorexia nervosa and improve mood and weight.
CONDITIONS
Official Title
Metreleptin in Anorexia Nervosa
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Current diagnosis of anorexia nervosa according to DSM-5 confirmed by clinical interview
- Body mass index (BMI) greater than 13 kg/m2 and less than or equal to 18 kg/m2
- Body weight at least 35 kg
- Hospitalized in the Eating Disorders Unit at University Hospital of Zurich
- Ability to understand German
- Age between 17 and 65 years
- Depressive symptoms with Hamilton Depression Scale (HAMD-17) score of 8 or higher
- Negative urine pregnancy test, not breastfeeding, and using two forms of birth control
- Signed informed consent
You will not qualify if you...
- Illicit drug use within the last month or current alcohol use disorder
- Severe psychiatric disorders such as schizophrenia or bipolar disorder
- Severe medical conditions including inflammatory bowel disease, diabetes, autoimmune disorders, pancreatitis, neurological disorders, or cancer including lymphoma
- Acute suicidal thoughts or serious self-injury
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Eating Disorder Unit, Clinic of Consultation-Liaison Psychiatry and Psychosomatic Medicine, University Hospital Zurich
Zurich, Canton of Zurich, Switzerland, 8091
Actively Recruiting
Research Team
G
Gabriella Milos, Prof. Dr. med.
CONTACT
L
Lisa Guth, MSc Psychology
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here