Actively Recruiting
Metronidazole as Preoperative Therapy in CRC / FusoMetro-001
Led by Oncology Institute of Southern Switzerland · Updated on 2025-11-18
40
Participants Needed
1
Research Sites
172 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The proposed proof-of concept trial aims at determining the effectiveness of metronidazole in decreasing the Fusobacterium nucleatum load in tissues and possibly on its detrimental effects on tumor cells and tumor microenvironment.
CONDITIONS
Official Title
Metronidazole as Preoperative Therapy in CRC / FusoMetro-001
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Provided written informed consent according to ICH/GCP regulations before registration
- Age 18 years or older
- Untreated, primary colorectal adenocarcinoma located more than 15 cm from the anal verge
- Colonoscopy with endoscopic biopsy confirming disease
- Scheduled for surgical tumor removal before any other therapy
You will not qualify if you...
- Insufficient biopsy material for further evaluation
- Known allergy to metronidazole or nitroimidazole derivatives
- Use of oral or parenteral antibiotics within 6 weeks before enrollment
- Emergency surgery planned within less than 14 days before treatment start
- Other cancer within 5 years except certain skin cancers and cervical carcinoma in situ
- Previous anticancer treatment before surgery
- Pregnant or breastfeeding women
- Fertile patients not using safe contraception during the study
- Significant other diseases such as kidney, liver, or heart problems
- Inability to consent or follow study procedures due to language or psychological issues
- Participation in another drug trial within 30 days before or during this study
- Any serious medical, psychiatric, familial, or geographical condition interfering with treatment or compliance
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Oncology Institute of Southern Switzerland
Bellinzona, Canton Ticino, Switzerland, 6500
Actively Recruiting
Research Team
S
Sara De Dosso, MD
CONTACT
L
Luigi Tortola, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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