Actively Recruiting
Michigan Food and Atopic Dermatitis (M-FAD) Program - Molecular Analytics Project
Led by University of Michigan · Updated on 2025-11-25
200
Participants Needed
1
Research Sites
158 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will explore potential links between atopic dermatitis and food allergy. This information will be useful to determine atopic dermatitis and food allergy share unique biochemical or genetic identifiers useful for diagnosing and treatments in the future. This is a mechanistic study consisting of obtaining blood and skin samples from participants at baseline. Individuals may also undergo a clinically indicated oral food challenge and have blood and skin samples collected at various times during the oral food challenge. This study will create a molecular map of the pathology of atopic dermatitis and food allergy. This information will be deployed to evaluate the hypothesis that atopic dermatitis and food allergy share unique genetic transcriptional signals in which the study team can then further analyze pathological pathways and cell types.
CONDITIONS
Official Title
Michigan Food and Atopic Dermatitis (M-FAD) Program - Molecular Analytics Project
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Known history of food anaphylaxis to peanut, tree nut, egg, milk, or sesame confirmed by an allergist (food allergy groups)
- Skin and blood food allergy testing within the past 6 months meeting positive predictive value thresholds (food allergy groups)
- No history of atopic dermatitis (food allergy only group)
- Atopic dermatitis diagnosis by allergist and/or dermatologist (atopic dermatitis without food allergy group)
- No history of food allergy (atopic dermatitis without food allergy group)
- No history of food allergy or atopic dermatitis (control group)
- Age between 10 and 55 years
You will not qualify if you...
- Younger than 10 years or older than 55 years
- Any active cardiovascular disease, cancer, pulmonary disease except well-controlled asthma, or other conditions preventing safe oral food challenge
- Use of medications interfering with oral food challenge that cannot be stopped temporarily, including antihistamines within 1 week
- Skin conditions other than atopic dermatitis that affect the study, such as autoimmune skin diseases or hyper-IgE syndromes
- Recent changes (within 6 months) in biologic medications affecting atopic dermatitis or food allergy
- Past or present oral immunotherapy for any food allergen
- Pregnancy or unwillingness to self-report pregnancy status for females of childbearing age
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Michigan
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
Research Team
B
Bridgette Kaul
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
5
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