Observational Study of Micro-expressions and Brain Activity in Adults with Prolonged Consciousness Disorders

What this Trial Is About

This research aims to understand micro-expressions in patients with prolonged disorders of consciousness. It focuses on how emotional stimuli might induce micro-expression changes in these patients and uses these changes to classify levels of consciousness. The study also seeks to assist clinical diagnosis by detecting micro-expressions and explore residual brain function through monitoring these expressions, supported by assessments like the CRS-R scale. About 200 participants will be involved, including 150 patients with consciousness disorders and 50 healthy controls matched by age and gender. Participants will undergo assessments using the CRS-R scale to evaluate auditory, visual, motor, speech responsiveness, communication, and arousal levels. Researchers will record facial expressions, collect EEG data, and perform MRI scans during exposure to various emotional stimuli. The study dataset will be split into training and testing sets using machine learning methods. The study includes both patients with disorders of consciousness and healthy participants as control subjects. During the study, participants will have multiple CRS-R assessments and their micro-expressions monitored. Follow-up evaluations using the CRS-R and GOS scales will be conducted over a six-month period to track progress. Researchers will analyze the GOSE and CRS-R scores at six months as primary outcomes. General participant information, including medical and family history, will also be collected to support the research objectives.

Micro-expressions in Patients With Prolonged Disorders of Consciousness