Actively Recruiting
Study of Micro-expressions in Patients With Prolonged Disorders of Consciousness
Led by First Affiliated Hospital of Zhejiang University · Updated on 2026-01-14
200
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
F
First Affiliated Hospital of Zhejiang University
Lead Sponsor
H
Hangzhou Mingzhou Brain Rehabilitation Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to understand micro-expressions in patients with prolonged disorders of consciousness. It focuses on how emotional stimuli might induce micro-expression changes in these patients and uses these changes to classify levels of consciousness. The study also seeks to assist clinical diagnosis by detecting micro-expressions and explore residual brain function through monitoring these expressions, supported by assessments like the CRS-R scale. About 200 participants will be involved, including 150 patients with consciousness disorders and 50 healthy controls matched by age and gender. Participants will undergo assessments using the CRS-R scale to evaluate auditory, visual, motor, speech responsiveness, communication, and arousal levels. Researchers will record facial expressions, collect EEG data, and perform MRI scans during exposure to various emotional stimuli. The study dataset will be split into training and testing sets using machine learning methods. The study includes both patients with disorders of consciousness and healthy participants as control subjects. During the study, participants will have multiple CRS-R assessments and their micro-expressions monitored. Follow-up evaluations using the CRS-R and GOS scales will be conducted over a six-month period to track progress. Researchers will analyze the GOSE and CRS-R scores at six months as primary outcomes. General participant information, including medical and family history, will also be collected to support the research objectives.
CONDITIONS
Brief Title
Micro-expressions in Patients With Prolonged Disorders of Consciousness
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with consciousness disorders for more than 28 days following severe brain injury, assessed by the CRS-R scale to meet the criteria for VS or MCS
- Aged between 18 and 80 years
- Stable vital signs
- Voluntary participation of family members with signed informed consent
- Good cooperation, minimal facial and spontaneous activities, no use of antiepileptic or sedative drugs
You will not qualify if you...
- Locked-in syndrome
- Contraindications for EEG examination
- Contraindications for MRI scanning, such as the presence of internal metallic implants
- Diseases and factors that may affect brain function assessment, such as metabolic disorders, poisoning, shock, etc.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Single session
Participants undergo assessments including facial expression recording, EEG, and MRI scans to evaluate micro-expressions and brain function.
1 visit (in-person)
Duration - Ongoing during study participation
Participants are assessed multiple times using the CRS-R scale to evaluate auditory, visual, motor, speech responsiveness, communication, and arousal levels.
Multiple assessment visits
Duration - 6 months
Follow-up evaluations with CRS-R and GOS scales are conducted over a period of 6 months after initial assessments.
Follow-up visits during 6 months
Trial Site Locations
Total: 1 location
1
First Affiliated Hospital,Zhejiang University
Hangzhou, Zhejiang, China, 310003
Actively Recruiting
Research Team
F
Fangping He, Master
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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