Actively Recruiting
Study of Micro-movements in Patients With Prolonged Disorders of Consciousness
Led by First Affiliated Hospital of Zhejiang University · Updated on 2026-01-14
179
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
F
First Affiliated Hospital of Zhejiang University
Lead Sponsor
H
Hangzhou Mingzhou Brain Rehabilitation Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating micro-movements in patients with prolonged disorders of consciousness to better understand their remaining brain function and consciousness levels. This observational study aims to use a neuropsychological model to monitor micro-movements, classify consciousness levels accurately, and identify patients with cognitive-motor dissociation to improve cognitive prognosis. The research also seeks to explore neural mechanisms underlying chronic disorders of consciousness. About 178 participants will be enrolled, including approximately 89 patients with prolonged disorders of consciousness and 89 healthy volunteers matched by age and gender. Participants will undergo assessments using the CRS-R scale for auditory, visual, motor, speech, communication, and arousal responses. Researchers will record micro-movements in reaction to emotional stimuli and collect electroencephalogram (EEG) and MRI data. The study data will be split into training and testing sets using a machine learning algorithm. Participants will be followed for six months with evaluations using the CRS-R and Glasgow Outcome Scale-Extended (GOSE) to measure recovery outcomes. Medical history and demographic information will also be collected. The main outcome is the GOSE score at six months, with CRS-R scores as secondary outcomes. This study is sponsored by the First Affiliated Hospital of Zhejiang University and will run until late 2026.
CONDITIONS
Brief Title
Micro-movements in Patients With Prolonged Disorders of Consciousness
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with consciousness disorders for more than 28 days following severe brain injury, meeting criteria for vegetative state or minimally conscious state by CRS-R scale
- Aged between 18 and 80 years
- Stable vital signs
- Voluntary participation of family members with signed informed consent
- Good cooperation with minimal facial and spontaneous activities, no use of antiepileptic or sedative drugs
You will not qualify if you...
- Locked-in syndrome
- Contraindications for EEG examination
- Contraindications for MRI scanning, such as internal metallic implants
- Diseases or factors affecting brain function assessment (e.g., metabolic disorders, poisoning, shock)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single session
Participants undergo assessments including micro-movement recording, electroencephalogram (EEG), and MRI scanning to evaluate brain function and responses to emotional stimuli.
1 visit (in-person)
Duration - 6 months
Participants are followed for 6 months with evaluations using the CRS-R and GOS scales to monitor recovery and outcomes.
Follow-up visits during 6 months
Trial Site Locations
Total: 1 location
1
First Affiliated Hospital,Zhejiang University
Hanzhou, Zhejiang, China, 310003
Actively Recruiting
Research Team
Z
Zhuolin He
B
Benyan Luo
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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