Actively Recruiting
Micro-movements in Patients With Prolonged Disorders of Consciousness
Led by First Affiliated Hospital of Zhejiang University · Updated on 2026-01-14
179
Participants Needed
1
Research Sites
134 weeks
Total Duration
On this page
Sponsors
F
First Affiliated Hospital of Zhejiang University
Lead Sponsor
H
Hangzhou Mingzhou Brain Rehabilitation Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to learn about the micro-movements in patients with prolonged disorders of consciousness. The main questions it aims to answer are: Use the neuropsychological paradigm model to monitor micro-movements, assess the patient's remaining level of consciousness and accurately classify it; screen out patients with cognitive-motor dissociation to improve the prognosis of cognitive function; explore the remaining brain function of patients with chronic disorders of consciousness and promote relevant study of neural mechanisms. Participants will be subjected to consciousness assessment by CRS-r scale, and their micro-movement changes in response to various emotional stimuli will be captured, along with the collection of EEG and MRI data. Follow-up evaluations will be conducted using the CRS-R scale and GOS scale, with a follow-up period of 6 months.
CONDITIONS
Official Title
Micro-movements in Patients With Prolonged Disorders of Consciousness
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with consciousness disorders lasting more than 28 days after severe brain injury, meeting criteria for vegetative state or minimally conscious state by CRS-R scale
- Age between 18 and 80 years
- Stable vital signs
- Voluntary participation with signed informed consent from family members
- Good cooperation, minimal facial and spontaneous activity, no use of antiepileptic or sedative drugs
You will not qualify if you...
- Diagnosis of locked-in syndrome
- Contraindications for EEG examination
- Contraindications for MRI scanning, such as internal metallic implants
- Diseases or factors affecting brain function assessment, including metabolic disorders, poisoning, or shock
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
First Affiliated Hospital,Zhejiang University
Hanzhou, Zhejiang, China, 310003
Actively Recruiting
Research Team
Z
Zhuolin He
CONTACT
B
Benyan Luo
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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