Study of Micro-movements in Adults With Prolonged Consciousness Disorders Using EEG and MRI

What this Trial Is About

Researchers are investigating micro-movements in patients with prolonged disorders of consciousness to better understand their remaining brain function and consciousness levels. This observational study aims to use a neuropsychological model to monitor micro-movements, classify consciousness levels accurately, and identify patients with cognitive-motor dissociation to improve cognitive prognosis. The research also seeks to explore neural mechanisms underlying chronic disorders of consciousness. About 178 participants will be enrolled, including approximately 89 patients with prolonged disorders of consciousness and 89 healthy volunteers matched by age and gender. Participants will undergo assessments using the CRS-R scale for auditory, visual, motor, speech, communication, and arousal responses. Researchers will record micro-movements in reaction to emotional stimuli and collect electroencephalogram EEG and MRI data. The study data will be split into training and testing sets using a machine learning algorithm. Participants will be followed for six months with evaluations using the CRS-R and Glasgow Outcome Scale-Extended GOSE to measure recovery outcomes. Medical history and demographic information will also be collected. The main outcome is the GOSE score at six months, with CRS-R scores as secondary outcomes. This study is sponsored by the First Affiliated Hospital of Zhejiang University and will run until late 2026.

Micro-movements in Patients With Prolonged Disorders of Consciousness