Actively Recruiting
Microbial Colonization Distribution and Adaptive Evolution of Lower Respiratory Tract in Bronchiectasis Patients.
Led by Second Affiliated Hospital, School of Medicine, Zhejiang University · Updated on 2025-11-20
1850
Participants Needed
1
Research Sites
362 weeks
Total Duration
On this page
Sponsors
S
Second Affiliated Hospital, School of Medicine, Zhejiang University
Lead Sponsor
Z
Zhejiang Provincial People's Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Qualified sputum samples from bronchiectasis patients were collected regularly every month for three consecutive years to analyze the microbiome changes of lower respiratory tract of bronchiectasis patients by metagenomic sequencing. Pseudomonas aeruginosa was isolated and the whole genome was sequenced to analyze the adaptive evolution，including virulence, quorum sensing and drug resistance under host pressure. The aim of the study is to clarify the rule of microflora colonization distribution and adaptive evolution in the lower respiratory tract of patients with bronchiectasis, to predict the acute attack and prognosis of patients with microbiome changes, and to find more new prevention and treatment methods by adjusting the microbiome of the lower respiratory tract.
CONDITIONS
Official Title
Microbial Colonization Distribution and Adaptive Evolution of Lower Respiratory Tract in Bronchiectasis Patients.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Bronchiectasis patients in clinically stable period
- Two or more chest infections in the previous year
- Chest CT confirmed bronchiectasis with bronchial to arterial ratio greater than 1
- Chronic colonization of Pseudomonas aeruginosa and clinically stable for 6 months prior to study
You will not qualify if you...
- Illness deterioration defined by at least 24 hours of three or more symptoms such as increased cough, increased sputum volume, purulent sputum, hemoptysis, increased dyspnea, increased wheezing, fever (≥38°C), or discomfort requiring antibiotics
- Current smokers or former smokers who quit less than 1 year ago, with smoking history over 15 pack-years, or CT showing emphysema
- Patients with cystic fibrosis
- Active allergic bronchopulmonary aspergillosis
- Active tuberculosis patients
- Patients with poor asthma control
- Pregnant or breastfeeding women
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
2ndAffiliated Hospital, School of Medicine, Zhejiang University
Hangzhou, Zhejiang, China
Actively Recruiting
Research Team
F
Feng Xu, Doctor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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