Actively Recruiting

Phase 2
Age: 18Years +
FEMALE
NCT05020574

Microbiome and Association With Implant Infections

Led by University of California, San Francisco · Updated on 2026-03-18

200

Participants Needed

1

Research Sites

274 weeks

Total Duration

On this page

Sponsors

U

University of California, San Francisco

Lead Sponsor

T

The Plastic Surgery Foundation

Collaborating Sponsor

AI-Summary

What this Trial Is About

The most common tissue expander-related infections are from Staphylococcus and Pseudomonas species. In addition, from breast tissue microbiome studies, Staphylococcus and Pseudomonas show variable abundance across samples. The investigator hypothesizes that participants undergoing mastectomy with high initial abundance of Staphylococcus and/or Pseudomonas are more likely to develop subsequent tissue expander-related infections from these respective organisms.

CONDITIONS

Official Title

Microbiome and Association With Implant Infections

Who Can Participate

Age: 18Years +
FEMALE

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients must have histologically confirmed breast malignancy OR genetic predisposition to breast cancer.
  • Age 18 years or older.
  • Scheduled to undergo mastectomy with immediate placement of tissue expanders or implant.
  • Able to understand and willing to sign informed consent.
  • At least 4 weeks since completing chemotherapy or radiation therapy.
Not Eligible

You will not qualify if you...

  • Any significant medical condition or lab abnormalities that increase risk for study participation.
  • Pregnant or breastfeeding.
  • Taken antibiotics within 90 days before consent.
  • Taken probiotics within 90 days before consent.
  • Known allergy to study antibiotics.
  • Male patients.

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

University of California, San Francisco

San Francisco, California, United States, 94143

Actively Recruiting

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Research Team

L

Laura Barnes, MD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

SUPPORTIVE_CARE

Number of Arms

2

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Microbiome and Association With Implant Infections | DecenTrialz