Actively Recruiting
Microbiome and Metabolome Profiles in Couples Undergoing IVF and Reproductive Outcomes
Led by Karolinska Institutet · Updated on 2026-04-16
1000
Participants Needed
3
Research Sites
350 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This prospective observational cohort study investigates the role of the microbiome and metabolome in couples undergoing in vitro fertilization. Biological samples will be collected from both female and male partners, including semen, vaginal, and blood samples, to characterize microbial composition and metabolic profiles. The study aims to examine how these biological profiles are associated with reproductive outcomes such as fertilization, pregnancy, miscarriage, and live birth. Participants will be followed longitudinally, and reproductive and obstetric outcomes will be obtained through linkage with national health registers.
CONDITIONS
Official Title
Microbiome and Metabolome Profiles in Couples Undergoing IVF and Reproductive Outcomes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged 18 to 40 years at enrolment.
- Men aged between 18 to 56 years at enrolment.
- Couples planning to undergo IVF treatment at a participating centre.
- Sufficient understanding of spoken and written Swedish or English to provide informed consent and complete the web-based questionnaire.
You will not qualify if you...
- Pregnancy at the time of enrolment (confirmed or suspected).
- Recent systemic antibiotic use within the past 4 weeks.
- Active vaginal or genital tract infection at the time of sampling.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Reproduktionsmottagning Malmö, Skånes universitetssjukhus
Malmö, Sweden
Actively Recruiting
2
Karolinska Universitetssjukhuset
Stockholm, Sweden, 146 32
Actively Recruiting
3
Reproduktionscenter, Akademiska sjukuhset
Uppsala, Sweden
Actively Recruiting
Research Team
O
Ola Larsson, PhD
CONTACT
H
Hanna Nilsson, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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